... behavior. Sidekick is required in photoreceptors, but not in their target lamina neurons, to promote the alignment of lamina neurons into columns and subsequent sorting of photoreceptor axons into synaptic modules based on their precise spatial orientation. Sidekick is also localized to the dendrites...

...Daiki Umetsu; Satoshi Murakami; Makoto Sato; Tetsuya Tabata During development of the Drosophila visual center, photoreceptor cells extend their axons (R axons) to the lamina ganglion layer, and trigger proliferation and differentiation of synaptic partners (lamina neurons) by delivering...

...Kirsten-Andr Senti; Krystyna Keleman; Frank Eisenhaber; Barry J. Dickson ABSTRACT Photoreceptors in the Drosophila eye project their axons retinotopically to targets in the optic lobe of the brain. The axons of photoreceptor cells R1-R6 terminate in the first optic ganglion, the lamina, while R7...

...Zhen Huang; Samuel Kunes ABSTRACT The arrival of retinal axons in the brain of Drosophila triggers the assembly of glial and neuronal precursors into a ‘neurocrystalline’ array of lamina synaptic ‘cartridges’. Hedgehog, a secreted protein, is an inductive signal delivered by retinal axons...

...Brian A. Mozer; Seymour Benzer ABSTRACT The development of the lamina, the first optic ganglion of the fly visual system, depends on inductive cues from the innervating photoreceptor axons. lacZ expression from a Pelement insertion, A72, occurs in the anlage of the lamina coincident with axon...