... mice to unravel the impact of Eda signaling on lacrimal gland formation, maturation and subsequent physiological function. Our study demonstrates that Eda activity is dispensable during lacrimal gland embryonic development. However, using a transcriptomic approach, we show that the Eda pathway...

...D'Juan T. Farmer; Sara Nathan; Jennifer K. Finley; Kevin Shengyang Yu; Elaine Emmerson; Lauren E. Byrnes; Julie B. Sneddon; Michael T. McManus; Aaron D. Tward; Sarah M. Knox The tear-producing lacrimal gland is a tubular organ that protects and lubricates the ocular surface. The lacrimal gland...

... the expression of Sox10 to promote the formation of secretory acinar lobes in the lacrimal gland. Sox9 and FGF signaling were required for the expression of cartilage-associated extracellular matrix components during early stage lacrimal gland development. Fgfr2 deletion in the ocular surface epithelium reduced...

... mesenchyme, Ugdh mutation leads to excessive dispersion of Fgf10 protein, which fails to elicit an FGF signaling response or budding morphogenesis in the presumptive lacrimal gland epithelium. This is supported by genetic rescue experiments in which the Ugdh lacrimal gland defect is ameliorated...

...Cindy Tsau; Masataka Ito; Anastasia Gromova; Matthew P. Hoffman; Robyn Meech; Helen P. Makarenkova The lacrimal gland (LG) develops through branching morphogenesis and produces secretions, including tears, that lubricate and protect the ocular surface. Despite the prevalence of LG disorders...

...Yi Pan; Christian Carbe; Andrea Powers; Gen-Sheng Feng; Xin Zhang Shp2/Ptpn11 tyrosine phosphatase is a general regulator of the RTK pathways. By genetic ablation, we demonstrate that Shp2 is required for lacrimal gland budding, lens cell proliferation, survival and differentiation. Shp2 deletion...

...Yi Pan; Christian Carbe; Andrea Powers; Eric E. Zhang; Jeffrey D. Esko; Kay Grobe; Gen-Sheng Feng; Xin Zhang Preferential outgrowth of the bud cells forms the basis of branching morphogenesis. Here, we show that lacrimal gland development requires specific modification of heparan sulfates by Ndst...

...Charlotte Dean; Masataka Ito; Helen P. Makarenkova; Sonya C. Faber; Richard A. Lang The lacrimal gland provides an excellent model with which to study the epithelial-mesenchymal interactions that are crucial to the process of branching morphogenesis. In the current study, we show that bone...

...Helen P. Makarenkova; Masataka Ito; Venkatesh Govindarajan; Sonya C. Faber; Li Sun; Gerald McMahon; Paul A. Overbeek; Richard A. Lang ABSTRACT We investigated the mechanism of tissue induction and specification using the lacrimal gland as a model system. This structure begins its morphogenesis...