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Keywords: LR asymmetryClose
Jacob Hecksher-Sørensen, Robert P. Watson, Laura A. Lettice, Palle Serup, Lorraine Eley, Carlo De Angelis, Ulf Ahlgren, Robert E. Hill
Development (2004) 131 (19): 4665–4675.
Published: 01 October 2004
... and pancreatic laterality is dependent on a specialised, columnar mesodermal-derived cell layer referred to here as the splanchnic mesodermal plate (SMP). At early embryonic stages, the SMP is bilateral, surrounding the midline-located stomach and dorsal pancreatic bud. Under control of the LR asymmetry pathway...
Development (2002) 129 (20): 4685–4696.
Published: 15 October 2002
... genes that establish and maintain LR asymmetry, including expression of Nodal , Lefty2 and cryptic. Our genetic loss-of-function studies alone do not address the specific role of LPM-produced Bmp4 in regulating Nodal signaling in the LPM. We therefore took an alternative approach and inhibited...