...Patrick Narbonne; Vincent Hyenne; Shaolin Li; Jean-Claude Labbé; Richard Roy The protein kinase LKB1 is a crucial regulator of cell growth/proliferation and cell polarity and is the causative gene in the cancer-predisposing disease Peutz-Jeghers syndrome (PJS). The activity of LKB1 is greatly...

... suppressor kinase, LKB1, in the presence of a pseudokinase, STRADα, initiates axonal differentiation and growth through activating the SAD kinases in vertebrate neurons. STRADα was implicated in the localization, stabilization and activation of LKB1 in various cell culture studies. Its in vivo functions...

...Anou Londesborough; Kari Vaahtomeri; Marianne Tiainen; Pekka Katajisto; Niklas Ekman; Tea Vallenius; Tomi P. Mäkelä Inactivation of the tumor suppressor kinase Lkb1 in mice leads to vascular defects and midgestational lethality at embryonic day 9-11 (E9-E11). Here, we have used conditional...

...Silvia Bonaccorsi; Violaine Mottier; Maria Grazia Giansanti; Bonnie J. Bolkan; Byron Williams; Michael L. Goldberg; Maurizio Gatti We have isolated lethal mutations in the Drosophila lkb1 gene( dlkb1 ), the homolog of C. elegans par-4 and human LKB1 ( STK11 ), which is mutated in Peutz-Jeghers...

...Patrick Narbonne; Richard Roy In C. elegans , reduced insulin-like signalling induces developmental quiescence, reproductive delay and lifespan extension. We show here that the C. elegans orthologues of LKB1 and AMPK cooperate during conditions of reduced insulin-like signalling to establish cell...