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Keywords: LIF
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Journal Articles
Journal: Development
Development (2015) 142 (20): 3488–3499.
Published: 15 October 2015
...Sophie M. Morgani; Joshua M. Brickman Embryonic stem cells (ESCs) are pluripotent cell lines that can be maintained indefinitely in an early developmental state. ESC culture conditions almost always require the cytokine LIF to maintain self-renewal. As ESCs are not homogeneous but contain multiple...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (23): 4457–4467.
Published: 1 December 2014
... embryonic germ cells (EGCs) in culture in the presence of particular extracellular factors, such as combinations of Steel factor (KITL), LIF and bFGF (FGF2). Early PGCs form EGCs more readily than do later PGCs, and PGCs lose the ability to form EGCs by embryonic day (E) 15.5. Here, we examined the effects...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (16): 3311–3322.
Published: 15 August 2013
...Marie-Emmanuelle Mathieu; Corinne Faucheux; Claire Saucourt; Fabienne Soulet; Xavier Gauthereau; Sandrine Fédou; Marina Trouillas; Nadine Thézé; Pierre Thiébaud; Hélène Boeuf Pluripotent mouse embryonic stem cells (mESCs), maintained in the presence of the leukemia inhibitory factor (LIF) cytokine...
Includes: Supplementary data
Journal Articles
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Journal Articles
Journal: Development
Development (2003) 130 (11): 2505–2512.
Published: 1 June 2003
...Koji Shimozaki; Kinichi Nakashima; Hitoshi Niwa; Tetsuya Taga Oct3/4 plays a critical role in maintaining embryonic stem cell pluripotency. Regulatable transgene-mediated sustained Oct3/4 expression in ES cells cultured in serum-free LIF-deficient medium caused accelerated differentiation...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2001) 128 (7): 1045–1057.
Published: 1 April 2001
... of the nephron. We have found that leukemia inhibitory factor (LIF) and transforming growth factor β 2 (TGFβ 2) are secreted by inductive rat bud cells and cooperate to enhance and accelerate renal tubule formation in uninduced rat metanephric mesenchymal explants. LIF alone or TGFβ 2 with fibroblast growth...
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Journal: Development
Development (1995) 121 (5): 1547–1557.
Published: 1 May 1995
...), basic fibroblast growth factor (bFGF) and murine leukaemia inhibitory factor/differentiation-inhibiting activity (LIF/DIA) all increased melanoblast numbers. SCF and LIF also slightly inhibited melanoblast differentiation, while cholera toxin and TPA promoted differentiation. Using some...
Journal Articles
Journal: Development
Development (1995) 121 (4): 1005–1014.
Published: 1 April 1995
... tissues, the effect of leukaemia inhibitory factor (LIF) and epidermal growth factor (EGF) on their activity was investigated. Both LIF and EGF, like the proteinases, have been implicated in peri-implantation development. Blastocysts collected on day 4 of pregnancy were cultured 2 days in TCM 199 + 10...
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Journal Articles
Journal: Development
Development (1993) 118 (1): 83–93.
Published: 1 May 1993
... the effect of coculture with NNC, suggesting that diffusible factors from NNC were involved in the inhibition of TH. The inhibitory effect of NNC–CM was mimicked by treatment of dissociate cultures with ciliary neurotrophic factor (CNTF) and leukemia inhibitory factor (LIF). However, immunoprecipitation...
Journal Articles
Journal: Development
Development (1991) 113 (1): 193.
Published: 9 January 1991
... structures. We report here that the factor known as LIF (leukaemia inhibitory factor), which regulates the differentiation and growth of embryonic-stem (ES) and other cells in culture, has little effect in vitro on growth or on ureteric-bud morphogenesis other than to stimulate the bifurcation process...