... receptor CXCR4. Interestingly, the absence of CXCR4 signaling in spinal MNs is known to result in improper extension of the axons into the dorsal side of the spinal cord. Here, we report that the MN-specific ISL1-LHX3 complex directly transactivates the Stam1 gene and that STAM1 functions in determining...

... Highlighted article: In the mouse spinal cord, single-stranded DNA binding proteins are key cofactors in LIM-containing complexes, recruiting histone-modifying enzymes to promote transcription. NLI Ldb1 Isl1 Lhx3 Motor neuron V2a-interneuron Spinal cord The LIM homeodomain (LIM-HD) family...

.... For example, in mouse and chick Lhx3 plays a pivotal role in the development of both cell classes. Here, we utilize the ability to recognize individual zebrafish neurons to examine the roles of Lhx3 and its paralog Lhx4 in the development of MNs and ventral INs. We show that Lhx3 and Lhx4 are expressed...

... these complexes and, thereby, this binary-cell-fate decision. * Authors for correspondence( [email protected] ; [email protected] ) 23 6 2009 © 2009. © 2009. 2009 LIM transcription factor Motor neuron V2a interneuron Cell-fate specification Ldb (NLI, CLIM, Chip) Lmo4 Isl1 Isl2 Lhx3...

... embryos. Its ancient paralog, lhx3 ( lim3 ),is expressed around the blastopore in amphioxus and ascidian, but not vertebrate, gastrulae. These two genes are thus implicated in organizer evolution, and we addressed the evolutionary origins of their blastoporal expression and organizer activity. Gene...

... of most specialized cell types. Little is known about the mechanism through which these genes promote pituitary development. In this study we determined that the hypoplasia in Lhx4 mutants results from increased cell death and that the reduced differentiation is attributable to a temporal shift in Lhx3...