...), which arise from a common lateral ganglionic eminence (LGE) progenitor. The molecular mechanisms of cell fate specification of these two neuronal subtypes are incompletely understood. Here, we found that deletion of murine Meis2 , which is highly expressed in the LGE and derivatives, led to a large...

...-dependent suppression of developmental patterning factors such as Pax6 and Gsx2. LGE Cerebral cortex Dorsoventral patterning Neural progenitor Neurogenesis Olfactory bulb Mouse Ministry of Education, Culture, Sports, Science and Technology 10.13039/501100001700 JP22700361...

... in the lateral ganglionic eminence (LGE). Using conditional deletion, we show that mice lacking the transcription factor genes Sp8 and Sp9 lose virtually all D2 MSNs as a result of reduced neurogenesis in the LGE, whereas D1 MSNs are largely unaffected. SP8 and SP9 together drive expression of the transcription...

... in turtle, but it is likely that some principles are conserved between sauropsids and mammals. In mammals,local and temporal variations in cell specification are likely to rely on the combinatorial expression of different transcription factors in different subregions (MGE, LGE and CGE...

... Mash1 and Dlx1/2 mutants affect distinct populations of LGE neurons, we suggest that bHLH and homeobox genes function coordinately to regulate differentiation at all stages of LGE development. Thus, although DLX1 and DLX2 are expressed in early neurons, their function does not appear to be essential...

... Gsh2 Pax6 Telencephalon Dorsoventral patterning LGE Ventral pallium Striatum Pallial/subpallial boundary CNS development Mouse In the last decade, significant inroads have been made into elucidating mechanisms that regulate dorsoventral (D/V) patterning in the mammalian spinal cord...