... signaling enables subsequent instructive signaling events that ensure progressive stages of heart valve development unfold in a coordinated manner. Heart valves Outflow tract Atrioventricular canal EMT Cushion mesenchyme Mitral valve Axin2 Lef1 Versican Tenascin Spongiosa Chordae tendineae...

... studies showed that neuromasts are deposited closer together and the PLLp terminates prematurely in lef1 -deficient zebrafish embryos. It was suggested that this results from reduced proliferation in the leading domain of the PLLp and/or premature incorporation of progenitors into proto-neuromasts. We...

... in the leading zone of the primordium and global Wnt inactivation leads to dramatic disorganization of the primordium and a loss of proto-NM formation. However, the exact cellular events that are regulated by the Wnt pathway are not known. We identified a mutant strain, lef1 nl2 , that contains a lesion...

... through Lef1 to regulate neurogenesis in the zebrafish hypothalamus. We show that Lef1 is required for proneural and neuronal gene expression, and for neuronal differentiation in the posterior hypothalamus. Furthermore, we find that this process is dependent on Wnt8b, a ligand of the canonical pathway...

... LRC and induces differentiation of sebocytes within the interfollicular epidermis. Expression of N-terminally truncated Lef1 to block β-catenin signalling induces transdifferentiation of hair follicles into interfollicular epidermis and sebocytes and causes loss of LRC primarily through proliferation...

... and Edar in wild type as well as Tabby and Lef1 mutant mouse embryos. We show that Eda and Edar expression is confined to the ectoderm and occurs in a pattern that suggests a role of ectodysplasin/Edar signaling in the interactions between the ectodermal compartments and the formation and function of hair...

... of ectodermal origin. We have investigated the molecular mechanisms of mammary placode development using Lef1 as a marker for the epithelial component of the placode, and mice deficient for Fgf10 or Fgfr2b , both of which fail to develop normal mammary glands. Mammary placode induction involves two different...

...Catherin Niemann; David M. Owens; Jörg Hülsken; Walter Birchmeier; Fiona M. Watt To examine the consequences of repressing β-catenin/Lef1 signalling in mouse epidermis, we expressed a ΔNLef1 transgene, which lacks the β-catenin binding site, under the control of the keratin 14 promoter. No skin...

... streak Gastrulation Nieuwkoop centre Vg1 Wnt Lef1 β-catenin JNK Crescent Dickkopf Frizzled 8 Chick Unlike amphibian embryos, where polarity is established by the third cleavage division through the localisation of maternal determinants (reviewed in Harland and Gerhart, 1997 ; Arendt...

... -catenin and Lef1 are expressed during somitogenesis. Lef1 and β -catenin transcripts become restricted to the developing myotome. Furthermore, β -catenin is expressed prior to the time at which MyoD transcripts can be detected. Expression of β -catenin mRNA is regulated by positive and negative signals...

... by Company of Biologists 2000 AMH MIS β-catenin LEF1 Müllerian duct regression Apoptosis Epitheliomesenchymal transformation Rat Mouse Hormones secreted by the fetal gonads control the differentiation of the reproductive tract and external genitalia. The experiments of Jost (1953...

...Dongsheng Duan; Yongping Yue; Weihong Zhou; Brett Lebed; Teresa C. Ritchie; Rudolf Grosschedl; John F. Engelhardt SUMMARY Previous studies have demonstrated that transcription of the lymphoid enhancer binding factor 1 ( Lef1 ) gene is upregulated in submucosal gland progenitor cells just prior...

... induction. Since Xtwn expression is strongly induced in ectodermal (animal cap) cells in response to overexpression of a dorsalizing Wnt molecule, we examined the possibility that Xtwn might be a direct target of a Wnt signal transduction cascade. First, we demonstrate that purified LEF1 protein can...