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Keywords: Kupffer's vesicle
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Journal Articles
Journal: Development
Development (2016) 143 (14): 2603–2615.
Published: 15 July 2016
...Junfeng Zhang; Zheng Jiang; Xingfeng Liu; Anming Meng The Kupffer's vesicle (KV) is the so-called left-right organizer in teleost fishes. KV is formed from dorsal forerunner cells (DFCs) and generates asymmetrical signals for breaking symmetry of embryos. It is unclear how DFCs or KV cells...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (9): 1817–1826.
Published: 01 May 2011
... formation during gastrulation with consequent cardia and viscera bifida. By contrast, depletion of miR-92 increased endoderm formation, which led to abnormal Kupffer's vesicle development and left-right patterning defects. Using target prediction algorithms and reporter constructs, we show that gata5...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (1): 45–54.
Published: 01 January 2011
... for normal LR development. However, the mechanisms involved in orienting LR asymmetric flow with previously established anteroposterior (AP) and dorsoventral (DV) axes remain poorly understood. In zebrafish, asymmetric flow is generated in Kupffer's vesicle (KV). The cellular architecture of KV is asymmetric...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (20): 3459–3468.
Published: 15 October 2010
... structure. Mechanical forces probably participate in this process but how they influence organ morphogenesis is still unclear. Here, we show that Wnt11- and Prickle1a-mediated planar cell polarity (PCP) signalling coordinates the formation of the zebrafish ciliated laterality organ (Kupffer's vesicle...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (16): 2753–2762.
Published: 15 August 2010
...Ludmila Francescatto; Sarah C. Rothschild; Alexandra L. Myers; Robert M. Tombes Intracellular calcium ion (Ca 2+ ) elevation on the left side of the mouse embryonic node or zebrafish Kupffer's vesicle (KV) is the earliest asymmetric molecular event that is functionally linked to lateral organ...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (10): 1621–1631.
Published: 15 May 2009
... pronephros and neural tube. Intriguingly,although seahorse mutations variably affect fluid flow in Kupffer's vesicle, they can have very weak effects on left-right patterning. Combined with recently published results, our alleles suggest that the function of seahorse in cilia motility is separable from its...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (16): 2807–2813.
Published: 15 August 2008
... of ciliated organs in laterality determination has been extensively studied, how they are formed during embryogenesis is still poorly understood. Here we show that Kupffer's vesicle (KV), the zebrafish organ of laterality, arises from a surface epithelium previously thought to adopt exclusively extra...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (8): 1907–1921.
Published: 15 April 2005
... epithelia, cilia are proposed to be non-motile sensory organelles, while in the mouse node, two cilia populations, motile and non-motile have been proposed to regulate situs. We show that cilia in the zebrafish larval kidney, the spinal cord and Kupffer's vesicle are motile, suggesting that fluid flow...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (6): 1247–1260.
Published: 15 March 2005
... (DFCs)express a conserved ciliary dynein gene ( left-right dynein-related1 , lrdr1 ) and form a ciliated epithelium inside a fluid-filled organ called Kupffer's vesicle (KV). Here, videomicroscopy demonstrates that cilia inside KV are motile and create a directional fluid flow just prior to the onset...
Includes: Multimedia, Supplementary data