... in any medium provided that the original work is properly attributed. Summary: Genome-edited larp6a and larp6b double-knockout zebrafish appear morphologically and behaviourally wild type and are fertile. Larp6 proteins are, however, required maternally for normal oocyte development...

..., leading to biliary cell differentiation. This study was undertaken to analyze how inactivation of the Cebpa gene affects biliary cell differentiation and gene expression of the regulatory genes for that differentiation, including Hnf1b and Hnf6 . In the knockout mouse liver at midgestation stages...

..., USA † These authors contributed equally to this work ‡ Present address: Hôpital Bichat–Claude-Bernard, 46 Rue Henri-Huchard, 75018 Paris, France 14 9 2005 ©2005. 2005 Homologous recombination Knockout Hypertrophic cartilage Chondrocyte Hereditary multiple...

... equally to this work 23 5 2005 ©2005. 2005 Foxa1 Knockout Prostate Foxa2 Shh Androgen Mouse Gene inactivation studies in the mouse, combined with organ culture and tissue recombination, have highlighted the essential roles of androgenic signaling and epithelial-stromal...

... environment for blood vessels to invade. * Authors for correspondence (e-mail: domi@itsa.ucsf.edu ; zena@itsa.ucsf.edu ) 25 9 2004 © 2004. 2004 Collagenase MMP Homologous recombination Knockout Hypertrophic cartilage Chondrocyte Trabecular bone Collagen Aggrecan Mouse...

... basement membrane protein knockouts, these data suggest that laminin is sufficient for basement membrane-like matrices during early development, but at later stages the specific composition of components including collagen IV defines integrity, stability and functionality. In contrast to invertebrates...

.... To delineate the effects of Math1 on CGC differentiation, we generated and studied primary cultures of CGC progenitors from Math1 / lacZ knockout mice. Rhombic lip precursors appeared properly positioned, expressed CGC-specific markers, and maintained Math1 promoter activity in vivo and in vitro,suggesting...

... GnRH neurons Peripheral nerve Peripheral neuropathy Dysmyelination Homologous recombination Knockout Targeted inactivation Gene targeting COE2 O/E3 Olf/Ebf genes ( Garel et al.,1997 ; Hagman et al.,1993 ; Malgaretti et al.,1997 ; Wang and Reed,1993 ; Wang et al.,1997 ) (reviewed...

... genetic data show that loss of Msx1 function does not rescue Splotch mutants to viability. Although we have not examined the hearts of Msx1-Pax3 double mutant embryos, the simplest explanation for this lack of rescue is that the Msx1 knockout fails to suppress the lethal cardiac defect of Splotch...

... mesenchyme development. Table 1. Table 2. *Author for correspondence (e-mail: dornitz@pcg.wustl.edu ) 14 3 2001 © 2001. 2001 FGF9 FGF FGF receptor Lung Mesenchyme Mouse Knockout Chicken lung graft experiments dating back to 1933 demonstrated...

... kinase NCK interacting kinase (NIK) misshapen Gastrulation knockout N-terminal JUN kinase (JNK) Mouse Ste20 kinases constitute a large family of protein kinases that are best known for their roles in activating the JNK MAP kinase pathway and in the regulation of the actin cytoskeleton...

... of telencephalic development. * Author for correspondence (email: fishell@saturn.med.nyu.edu ) 02 09 200 05 09 2000 © 2000 by Company of Biologists 2000 Mouse Telencephalon Knockout Gsh2 The telencephalon and diencephalon, which comprise the vertebrate forebrain, arise...

...@gwdg.de ) 04 08 2000 © 2000 by Company of Biologists 2000 Knockout Retina Retinal pigmented epithelium Pax Mouse The primordia, which give rise to the complex architecture of the mammalian eye, are regionalized and specified by autonomous as well as inductive cues ( Saha...

... targeting heart defect skeletal defect epithelial-mesenchymal interaction mouse knockout REFERENCES Abbott , B. D. and Birnbaum , L. S. ( 1990 ). Retinoic acid-induced alterations in the expression of growth factors in embryonic mouse palatal shelves . Teratology 42 , 597...

...-mail: christopher.nosrat@neuro.ki.se ) 18 03 1998 30 01 1998 © 1997 by Company of Biologists 1997 taste buds sensory organ gustatation neurotrophins knockout lingual Taste buds are chemosensory organs consisting of collections of spindle-shaped modified epithelial cells...