..., KLF4 and KLF5 have redundant roles in the downstream regulation of Nanog ( Jiang et al., 2008 ), KLF2 and KLF4 play redundant roles in regulating attachment between tendon and bone tissue ( Kult et al., 2021 ), whereas competition between KLF1 and KLF3 for binding sites can result in disparate...

... express Nanog and Gata6 , respectively. Fibroblast growth factor (FGF)–extracellular signal-regulated kinase (ERK) signalling is involved in segregation of the EPI and PrE lineages; however, the mechanism involved in Fgf4 regulation is poorly understood. Here, we identified Klf5 as an upstream repressor...

...-implantation embryo. Here, we show that Klf5 is required for the formation of the trophectoderm (TE) and the inner cell mass (ICM), and for repressing primitive endoderm (PE) development. Although cell polarity appeared normal, Klf5 mutant embryos arrested at the blastocyst stage and failed to hatch due...