... revealed dysregulation of vSMC differentiation, including downregulation of Klf4, which we find expressed in a subset of SPs. Stromal Klf4 deletion similarly resulted in decreased smooth muscle coverage and arterial branching without, however, the disruption of renal artery patterning and perfusion seen...

... of the last organs to mature in utero,premature infants born before 34 weeks gestation are at great risk for complications. The transcription factor kruppel-like factor 4 ( Klf4 ),has been shown by a targeted ablation, to have an essential function in barrier acquisition. We investigated whether Klf4...

...Jonathan P. Katz; Nathalie Perreault; Bree G. Goldstein; Catherine S. Lee; Patricia A. Labosky; Vincent W. Yang; Klaus H. Kaestner Klf4 (formerly GKLF) is a zinc-finger transcription factor expressed in the epithelia of the skin, lungs, gastrointestinal tract and several other organs. In vitro...