... ), which is in line with the marginal expression of endogenous ZFP708 in mESCs. The recruitment of TRIM28 to ZFP708 sites in the ZFP708 overexpression ESCs correlates with a specific increase of H3K9me3, suggesting the recruitment of not just TRIM28 but the whole KRAB-ZFP/TRIM28 machinery ( Fig. 2 E...

...Gabriela Ecco; Michael Imbeault; Didier Trono Krüppel-associated box domain zinc finger proteins (KRAB-ZFPs) are the largest family of transcriptional regulators in higher vertebrates. Characterized by an N-terminal KRAB domain and a C-terminal array of DNA-binding zinc fingers, they participate...