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Journal Articles

A multi-layered integrative analysis reveals a cholesterol metabolic program in outer radial glia with implications for human brain evolution

Juan Moriano, Oliviero Leonardi, Alessandro Vitriolo, Giuseppe Testa, Cedric Boeckx
Journal: Development
Development (2024) 151 (16): dev202390.
https://doi.org/10.1242/dev.202390
Published: 27 August 2024
... expression programs during indirect neurogenesis. In particular, our analysis uncovers a key role for a cholesterol program in outer radial glia, regulated by zinc-finger transcription factor KLF6. A cartography of the regulatory landscape impacted by Homo sapiens -derived variants reveals signals...
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Includes: Supplementary data