... to mediate nuclear migration. The LINC complex, consisting of the SUN protein UNC-84 and the KASH protein UNC-83, recruits dynein and kinesin-1 to the nuclear surface. Both motors function in P-cell nuclear migration, but dynein, functioning through UNC-83, plays a more central role as nuclei migrate towards...

...Xiaochang Zhang; Rener Xu; Binggen Zhu; Xiujuan Yang; Xu Ding; Shumin Duan; Tian Xu; Yuan Zhuang; Min Han Proper nuclear positioning is important to cell function in many biological processes during animal development. In certain cells, the KASH-domain-containing proteins have been shown...