... responses of the mammalian central nervous system. Using a chemical screen, we identify JNK signaling as a necessary regulator of glial cell cycling and tissue bridging during spinal cord regeneration in larval zebrafish. With a kinase translocation reporter, we visualize and quantify JNK signaling dynamics...

... signaling after amputation. Pharmacological inhibition of JNK signaling caused failure to induce hyperproliferation and resulted in regenerative defects. Such defects were abrogated by simultaneous knockdown of plac8-A expression. Thus, JNK-dependent suppression of plac8-A expression is indispensable...

... dendrite pruning in Drosophila . Pruning Raw JNK signaling Neuroglian Axon Dendrite During animal development, neurons often elaborate exuberant processes and connections at early stages. Selective elimination of their unnecessary processes without causing neuronal death, referred...

...: Ingestion of low amounts of bacteria induces a mild early stress response that triggers the proliferation of Drosophila midgut stem cells, with excess cells then eliminated by apoptosis. Opportunistic bacteria Apoptosis Cellular homeostasis Drosophila intestine JNK signaling Hippo signaling...

... checkpoint that allows regeneration to occur. This defect is likely to be caused by abnormally high expression of puckered , a negative regulator of Jun N-terminal kinase (JNK) signaling, at the wound site. Insufficient JNK signaling leads to insufficient expression of an insulin-like peptide, dILP8, which...

... components. Blocking Jun-N-terminal kinase (JNK) signaling, which can induce caspase-independent cell death, significantly rescued ventral eye loss in L or Ser mutants. However, blocking both caspase-dependent cell death and JNK signaling together showed stronger rescues of the L - or Ser- mutant eye...

... Molecular, Universidad Autonomo de Madrid, Madrid, Spain 20 02 2001 19 04 2001 © 2001 by Company of Biologists 2001 Drosophila oogenesis epithelial migrations JNK signaling dual specificity phosphatase small GTPase During organogenesis, tightly connected sheets...

...Ursula Weber; Nuria Paricio; Marek Mlodzik ABSTRACT Jun acts as a signal-regulated transcription factor in many cellular decisions, ranging from stress response to proliferation control and cell fate induction. Genetic interaction studies have suggested that Jun and JNK signaling are involved...