... cell nuclei in late oogenesis. Genetic analysis reveals that Srp acts downstream of JNK signaling to upregulate the expression of the phagocytic receptor Draper as well as other components in the corpse processing machinery. Our findings highlight the crucial role for Srp in non-professional phagocytes...

... to be dependent on cilia-driven fluid flow in the embryonic node. Planar cell polarity (PCP) signalling is crucial for patterning of nodal cilia, yet downstream effectors driving this process remain elusive. We have examined the role of the JNK gene family, a proposed downstream component of PCP signalling...

... in the Drosophila ovarian epithelial follicle stem cell (FSC) lineage. First, Ben is part of the JNK signaling pathway, and we found that it, as well as other JNK pathway genes, are essential for differentiation of FSC daughter cells. Our data suggest that JNK signaling promotes differentiation by suppressing...

..., Myc and Cyclin E are not required for either apical or basal cell extrusion induced by activation of this pathway. Another target gene, bantam , is only involved in basal cell extrusion, suggesting novel Hpo-regulated apical cell extrusion mechanisms. Using RNA-seq analysis, we found that JNK...

... with its STRIPAK partner, Connector of kinase to AP-1 ( Cka ), where they negatively regulate the Jun N-terminal kinase (JNK) signalling pathway. Our study reveals a novel role for Strip / Cka in JNK pathway regulation during spermatogenesis within the developing Drosophila testis. * Author...

...Sijun Zhu; Rui Chen; Peter Soba; Yuh-Nung Jan ABSTRACT Developmental pruning of axons and dendrites is crucial for the formation of precise neuronal connections, but the mechanisms underlying developmental pruning are not fully understood. Here, we have investigated the function of JNK signaling...

... survived and proliferated, newly formed spermatocytes enclosed by cyst cells lacking Par complex proteins died soon after onset of meiotic prophase. Loss of Par complex function resulted in stage-specific overactivation of the Jun-kinase (JNK) pathway in cyst cells. Knocking down expression of JNK pathway...

... al., 2017 ). Genetic evidence indicates that Toll-8 promotes NMJ growth independently of NF-κB signalling and via JNK instead ( Ballard et al., 2014 ). Toll-6 can also promote activity-dependent NMJ growth via JNK and FoxO, and downstream of Sarm, repressing the expression of the kinesin pavarotti...

... is proposed to be crucial for nuclear movement, is regulated by Nodal signaling and nuclear envelope proteins. The non-Smad JNK signaling pathway, which is downstream of Nodal signaling, regulates nuclear movement independently of the Smad pathway, and this nuclear movement is associated with Smad signal...

... response is mediated by JNK signalling from dying cells, but JNK functions differently in the trunk and the appendages, which may explain their distinct regenerative potential. * Author for correspondence ( [email protected] ) Competing interests The authors declare no competing or financial...

... protein Highwire (Hiw) during R7 growth cone halting, as has been observed in other systems. However, as R7 growth cones become boutons, Wnd levels are further repressed by a temporally expressed transcription factor, Tramtrack69 (Ttk69). Previously unobserved negative feedback from JNK also contributes...

...Marco La Fortezza; Madlin Schenk; Andrea Cosolo; Addie Kolybaba; Isabelle Grass; Anne-Kathrin Classen Tissue homeostasis relies on the ability of tissues to respond to stress. Tissue regeneration and tumour models in Drosophila have shown that c-Jun amino-terminal kinase (JNK) acts as a prominent...

... on a process of germline cyst breakdown during the perinatal period. The mechanisms regulating this process are poorly understood. Here we demonstrate that c-Jun amino-terminal kinase (JNK) signaling is crucial for germline cyst breakdown and primordial follicle formation. JNK was specifically localized...

.... During this dynamic process, the mechanisms that modulate intercellular adhesion to allow individual cells to change position without compromising structural integrity are not well understood. In vertebrates, Jun N-terminal kinase (JNK) is also required for tissue elongation, but the precise cellular...

...) that connects sumoylation to specific developmental signaling pathways remains relatively less clear. Here, we show that Smt3 knockdown in Drosophila wing discs causes phenotypes resembling JNK gain of function, including ectopic apoptosis and apoptosis-induced compensatory growth. Smt3 depletion leads...

... as the precise target cell remain undefined. Using a novel primary progenitor isolation system, we have investigated signal transduction and biological outcomes elicited by BMP7. We find that BMP7 directly and rapidly activates JNK signaling in nephron progenitors resulting in phosphorylation of Jun and ATF2...

... function of the JNK pathway. We propose that the compensatory growth is simply a homeostatic response of wing compartments, which resume growth after massive cellular loss until they reach the final correct size. The ectopic Dpp/Wg signalling associated with apoptosis is inconsequential in compartments...

... 2009. 2009 Neural induction Syndecan-4 FGF PKC Rac JNK AP-1 c-Fos The `default model' of neural induction proposes that neural development occurs as a result of the inhibition of BMP signalling in the embryonic ectoderm, and that in the absence of cell-cell signalling, ectodermal...

...) stimulation, RET can activate a variety of intracellular signals, including the Ras/mitogen-activated protein kinase, phosphatidylinositol 3-kinase(PI3K)/AKT, and RAC1/JUN NH 2 -terminal kinase (JNK) pathways. We recently demonstrated that the RAC1/JNK pathway is regulated by serine phosphorylation...

... Midbrain Morphogenesis Kinase JNK SNF-1 Vertebrate embryonic development proceeds through a cascade of inductive interactions, which specify major body axes and generate the three germ layers, ectoderm, mesoderm and endoderm, in the embryo. The Wnt pathway is among the few major signaling...