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Keywords: JAK/STAT
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Journal Articles
Journal: Development
Development (2022) 149 (8): dev199694.
Published: 26 October 2021
... that may modulate their survival. Through pharmacological perturbation, we demonstrate that Jak/Stat pathway activity is required for RGC survival after ONT. Furthermore, we show that immune responses directly contribute to RGC death after ONT; macrophages/microglia are recruited to the retina and blocking...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (3): dev171520.
Published: 1 February 2019
...: Lactobacilli-induced ROS generation in the Drosophila larval midgut is confined to enterocytes, whereas undifferentiated adult midgut progenitor cells exist in a distinguishable ‘ROS sheltered zone’. ROS Nrf2 Stem cell Non-cell autonomous Drosophila JAK/STAT Stem cell growth...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (16): 2907–2919.
Published: 15 August 2016
... stress-response pathway promoting injury-induced apoptosis and compensatory proliferation. A central question remaining unanswered is how both responses are balanced by activation of a single pathway. Signalling through the Janus kinase/Signal transducers and activators of transcription (JAK/STAT...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (6): 1073–1082.
Published: 15 March 2015
... for tumor formation. In the absence of Sxl protein, inappropriate Phf7 expression drives tumor formation through a cell-autonomous mechanism that includes sex-inappropriate activation of Jak/Stat signaling. Remarkably, tumor formation requires a novel response to external signals emanating from the GSC...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (13): 2808–2817.
Published: 1 July 2013
... regulator of BCC migration. Tj has a multifaceted impact on the known core cascade that enables BCC motility, consisting of the Jak/Stat signaling pathway, the C/EBP factor Slow border cells (Slbo), and the downstream effector DE-cadherin (DEcad). The initiation of BCC migration coincides with a Slbo...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (1): 56–65.
Published: 1 January 2013
.... Hh signaling cell-autonomously regulates CySC number and maintenance. The Hh and JAK/STAT pathways act independently and non-redundantly in CySC self-renewal. Finally, Hh signaling does not contribute to the niche function of CySCs, as Hh-sustained CySCs are unable to maintain GSCs in the absence...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (1): 195–204.
Published: 1 January 2013
... during follicle maturation as they are the only source of the JAK/STAT pathway ligand Unpaired (Upd), the morphogen activity of which instructs distinct follicle cell fates. Here we show that reduction of Upd levels leads to prolonged survival of supernumerary PCs, downregulation of the pro-apoptotic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (21): 4051–4061.
Published: 1 November 2012
.... * Author for correspondence ( erika.bach@nyu.edu ) Competing interests statement The authors declare no competing financial interests. 7 8 2012 © 2012. 2012 JAK/STAT Myc Cell competition During development, local interactions between cells influence their growth...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (21): 4627–4638.
Published: 1 November 2011
...) was recently shown to regulate Stat92E , the Janus kinase (JAK) and Signal transducer and activator of transcription (Stat) pathway effector, in the developing mesoderm. To understand whether the JAK/Stat pathway also regulates cardiogenesis, we performed a systematic characterization of JAK/Stat signaling...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (7): 1383–1393.
Published: 1 April 2011
... (BCs) are recruited and delaminate from the follicular epithelium. This process is triggered by the polar cells (PCs), which secrete the cytokine Unpaired (Upd) and activate the JAK/STAT pathway in neighbouring cells, turning them into invasive BCs. Interestingly, either a decrease or an increase in BC...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (24): 4147–4158.
Published: 15 December 2010
.... Intestinal stress induces the activation of Upd/Jak/Stat signalling, which promotes intestinal regeneration by inducing rapid stem cell proliferation. We have investigated the role of the Hippo (Hpo) pathway in the Drosophila intestine (midgut). Hpo pathway inactivation in either the ISCs...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (22): 3821–3830.
Published: 15 November 2009
... the sex chromosome constitution of the germ cells still plays some role at this time. The male soma signals to the germline through the JAK/STAT pathway, while the nature of the signal from the female soma remains unknown. We also find that the genes ovo and ovarian tumor ( otu ) are expressed in a female...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (8): 1471–1480.
Published: 15 April 2008
...' that sweeps toward more lateral NEs. l(1)sc expression is sufficient to induce NBs and is necessary for timely onset of NB differentiation. Thus, proneural wave precedes and induces transition of NE cells to NBs. Unpaired (Upd), the ligand for the JAK/STAT signaling pathway,is expressed in the most lateral NE...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (3): 533–540.
Published: 1 February 2008
... stem cell maintenance remain largely unknown. Here we demonstrate that removal of the Jak/Stat pathway in support cells of the Drosophila ovarian niche leads to germline stem cell loss by differentiation. Conversely,ectopic Jak/Stat activation in support cells induces stem cell tumours,implying...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (6): 1161–1169.
Published: 15 March 2007
... and inactivates Delta, reduces the level of Delta signaling between follicle cells, thereby limiting the size of the stalk. We find that Notch activation is required in a continuous fashion to maintain the polar and stalk cell fates. We further demonstrate that mutual antagonism between the Notch and JAK/STAT...
Journal Articles
Journal: Development
Development (2005) 132 (15): 3493–3504.
Published: 1 August 2005
... cells migrate from the anterior pole of the egg chamber towards the nurse cell-oocyte boundary. Yan expression is dependent on inputs from the JAK/STAT, Notch and Receptor Tyrosine Kinase pathways in border cells. Mechanistically, Yan functions to modulate the turnover of DE-Cadherin-dependent adhesive...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (13): 3069–3077.
Published: 1 July 2005
.... Apical capping is transient and is followed by rapid shedding prior to the initiation of BC migration, suggesting that the apical cap blocks migration. Consistently,non-migratory polar cells remain capped. We further show that JAK/STAT signalling and recruitment of outer BCs are required for correct...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2003) 130 (14): 3077–3084.
Published: 15 July 2003
...Stephen Brown; Nan Hu; James Castelli-Gair Hombría It is commonly accepted that activation of most signalling pathways is induced by ligand receptor dimerisation. This belief has been challenged for some vertebrate cytokine receptors of the JAK/STAT pathway. Here we study whether DOME...