... by Wnt16, directly instruct HSC fate in a shared vascular precursor. However, it remains unclear how this signaling cascade is spatially and temporally regulated within somites. Here, we show in zebrafish that an additional somitic Notch ligand, Jagged 2b (Jag2b), induces intercellular signaling to drive...

... Highlighted article : In the adult mouse lung, Notch3 identifies a population of parabasal cells and regulates the balance between basal and parabasal progenitor pools. Notch Basal cells p63 Airway differentiation Progenitor cells Lung regeneration Jagged COPD Basal cells are multipotent...

... interests. © 2011. Cis-inhibition Delta-like Signaling diversity Jagged Notch Notch intracellular domain Cells need to sense cues from their extracellular environment and integrate this information into appropriate developmental or physiological responses. Although...

...Elizabeth Zuniga; Frank Stellabotte; J. Gage Crump The development of the vertebrate face relies on the regionalization of neural crest-derived skeletal precursors along the dorsoventral (DV) axis. Here we show that Jagged-Notch signaling ensures dorsal identity within the hyoid and mandibular...

... by genes like BLADE ON PETIOLE1 ( BOP1 ), which prevent the development of ectopic meristematic activity that leads to the formation of new organs, and JAGGED ( JAG ), which control the proximodistal development of the leaf by regulating cell-division activity. We have isolated and characterized the BOP1...

...Kristin Lorent; Sang-Yeob Yeo; Takaya Oda; Settara Chandrasekharappa; Ajay Chitnis; Randolph P. Matthews; Michael Pack The Alagille Syndrome (AGS) is a heritable disorder affecting the liver and other organs. Causative dominant mutations in human Jagged 1 have been identified in most AGS patients...

...José R. Dinneny; Ramin Yadegari; Robert L. Fischer; Martin F. Yanofsky; Detlef Weigel Position-dependent regulation of growth is important for shaping organs in multicellular organisms. We have characterized the role of JAGGED , a gene that encodes a protein with a single C 2 H 2 zinc-finger...

... at the JAGGED ( JAG ) locus result in Arabidopsis plants with abnormally shaped lateral organs including serrated leaves, narrow floral organs, and petals that contain fewer but more elongate cells. jag mutations also suppress bract formation in leafy,apetala1 and apetala2 mutant backgrounds. The JAG gene...

... differentiation, but not specification, depends on Math1 , which acts by regulating the level of multiple components of the Notch signaling pathway. 12 11 2003 © 2004. 2004 Rhombic lip Cerebellum Cerebellar granule cells Neurite Notch Delta Jagged Hes Knockout Mouse The highly...