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Keywords: Isthmus
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Journal Articles
Journal: Development
Development (2006) 133 (13): 2467–2476.
Published: 01 July 2006
...@virus.kyoto-u.ac.jp ) * Present address: Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860-0811, Japan 12 4 2006 © 2006. 2006 bHLH Floor plate Isthmus Rhombomere boundary Roof plate Zona limitans intrathalamica Mouse The developing...
Journal Articles
Journal: Development
Development (2005) 132 (23): 5137–5145.
Published: 01 December 2005
... in the ganglionic eminence (GE),medial tegmentum (Tg), colliculus (C), isthmus (I), pons (P), medulla (M),spinal cord (S) and tongue (T) ( Fig. 1A ). ATBF1-expressing cells and BrdU-labeled cells were distinctly separated ( Fig. 1A,C1,C2 ). BrdU labeling in the proliferating zone and ATBF1 in the nucleus...
Journal Articles
Journal: Development
Development (2005) 132 (14): 3163–3173.
Published: 15 July 2005
.... Single morpholino knockdown of either Lmx1b.1 or Lmx1b.2 has no discernible effect on MMR development. Maintenance of lmx1b.1 and lmx1b.2 expression at the isthmus requires the function of no isthmus / pax2.1 , as well as Fgf signaling. Transient misexpression of Lmx1b.1 or Lmx1b.2 during early MMR...
Journal Articles
Journal: Development
Development (2005) 132 (2): 257–265.
Published: 15 January 2005
...Asuka Suzuki-Hirano; Tatsuya Sato; Harukazu Nakamura Fgf8 functions as an organizer at the mes/metencephalic boundary (isthmus). We showed that a strong Fgf8 signal activates the Ras-ERK signaling pathway to organize cerebellar differentiation. Sprouty2 is expressed in an overlapping manner to Fgf8...
Journal Articles
Journal: Development
Development (2004) 131 (17): 4275–4285.
Published: 01 September 2004
...Tatsuya Sato; Harukazu Nakamura The mes/metencephalic boundary (isthmus) is an organizing center for the optic tectum and cerebellum. Fgf8 is accepted as a crucial organizing signal. Previously, we reported that Fgf8b could induce cerebellum in the mesencephalon, while Fgf8a transformed...
Journal Articles
Journal: Development
Development (2004) 131 (14): 3285–3294.
Published: 15 July 2004
... Ci-Fgf8/17/18, CiDmbx and CiHox3 transcripts are co-localised posterior to Pax2/5/8, at the visceral ganglion ( Imai et al.,2002 ). In vertebrates, Fgf8 gene expression is caudal to the MHB isthmus, but slightly rostral to Dmbx1 and Hox gene expression which each start in rhomobomere 2( Irving...
Journal Articles
Journal: Development
Development (2003) 130 (22): 5319–5330.
Published: 15 November 2003
... domain upon which the cerebellum fuses. Elimination or overgrowth of this isthmic domain in Wnt1 sw/sw and En1 +/Otx2lacZ mutant mice, respectively, impair cerebellar midline fusion. Because the isthmus-derived midline cerebellar domain displays a distinct expression pattern of genes involved in BMP...
Journal Articles
Journal: Development
Development (2003) 130 (20): 4881–4893.
Published: 15 October 2003
.... The early pax2.1 expression marks the future midbrain and isthmus( Krauss et al., 1991a ; Lun and Brand, 1998 ). The expression of pax2.1 starts in two wings at midgastrula stage, 80% of epiboly, which fuse into one band at the tailbud stage( Fig. 1F )( Lun and Brand, 1998 ). Surprisingly, double...
Journal Articles
Journal: Development
Development (2002) 129 (24): 5779–5788.
Published: 15 December 2002
... fates. * Author for correspondence (e-mail: cliff@drugs.bsd.uchicago.edu ) 12 9 2002 ©2002. 2002 Bain nuclei Oculomotor neurons Red nucleus Homeobox genes Emx2 Sonic hedgehog FGF8 Isthmus Chick Mouse We thank S. Assimacopoulos for the pXeX- Fgf8 construct...
Journal Articles
Journal: Development
Development (2002) 129 (23): 5389–5398.
Published: 01 December 2002
... and also immediately posterior to it in anterior rhombomere 1. Axons of the most anterior cells follow a dorsal projection, which circumnavigates the isthmus, while those of more posterior trochlear neurons project anterodorsally to enter the isthmus. Once within the isthmus, axons form large fascicles...
Journal Articles
Journal: Development
Development (2002) 129 (22): 5269–5277.
Published: 15 November 2002
...Eiji Matsunaga; Tatsuya Katahira; Harukazu Nakamura The isthmus is the organizing center for the tectum and cerebellum. Fgf8 and Wnt1 are secreted molecules expressed around the isthmus. The function of Fgf8 has been well analyzed, and now accepted as the most important organizing signal...
Journal Articles
Journal: Development
Development (2002) 129 (13): 3227–3239.
Published: 01 July 2002
... of pax2.1 . Comparison of transgene expression in wild-type and homozygous pax2.1 mutant no isthmus (noi) embryos reveals that the transgene contains control element(s) for a novel, positive transcriptional feedback loop in MHB development. Transcription of endogenous pax2.1 at the MHB is known...
Journal Articles
Journal: Development
Development (2002) 129 (4): 905–916.
Published: 15 February 2002
...-cbg.de ) 3 12 2001 © 2002. 2002 pou2 Oct3/4 Pou5f1 Isthmus MHB Organizer pax2.1 spiel-ohne-grenzen Hindbrain Zebrafish The mechanisms involved in the formation of the various subdivisions of the brain share many common elements among vertebrates, making...
Journal Articles
Journal: Development
Development (2002) 129 (4): 917–933.
Published: 15 February 2002
... suggest that spg / pou2 is a transcription factor that mediates regional competence to respond to Fgf8 signaling. *Author for correspondence (e-mail: brand@mpi-cbg.de ) 27 11 2001 © 2002. 2002 Competence Fgf8 pou2 Oct3/4 Pou5f1 MHB Isthmus pax2 spiel-ohne-grenzen...
Journal Articles
Journal: Development
Development (2001) 128 (21): 4165–4176.
Published: 01 November 2001
... expression domains positions the MHB. How the positional information is translated into activation of Pax2 , Wnt1 and Fgf8 expression during MHB establishment remains unclear. In zebrafish spiel ohne grenzen ( spg ) mutants, the MHB is not established, neither isthmus nor cerebellum form, the midbrain...