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Keywords: Isthmic organizer
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Journal Articles
Journal: Development
Development (2008) 135 (12): 2093–2103.
Published: 15 June 2008
... secreted by the isthmic organizer located at the mes/r1 boundary( Wurst and Bally-Cuif, 2001 ; Zervas et al., 2005 ). Sonic hedgehog (Shh), expressed in the notochord and the ventral midline (floor plate) of the neural tube, controls specification of ventral cell types in the tegmentum and formation of...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (2): 317–325.
Published: 15 January 2007
... expression of Fgf8, Wnt1 and several isthmus-related transcription factors in the MHB, and is a crucial component of a cross-regulatory network required for the induction activity of the isthmic organizer in the MHB. Nissl staining and immunocytochemistry were performed as described( Ding et al., 2004...
Journal Articles
Journal: Development
Development (2006) 133 (15): 2793–2804.
Published: 01 August 2006
...Victor V. Chizhikov; Anne G. Lindgren; D. Spencer Currle; Matthew F. Rose; Edwin S. Monuki; Kathleen J. Millen During embryogenesis, the isthmic organizer, a well-described signaling center at the junction of the mid-hindbrain, establishes the cerebellar territory along the anterior/posterior axis...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (15): 2905–2913.
Published: 01 August 2006
...-hindbrain (MH) domain of the neural tube depend on the activity of a signaling center called the isthmic organizer(IsO), located at the constriction or isthmus that links the midbrain and hindbrain. Fibroblast growth factor 8 (FGF8), a diffusible molecule secreted by the IsO, is one of the major mediators...
Journal Articles
Journal: Development
Development (2006) 133 (9): 1779–1787.
Published: 01 May 2006
... territories of the central nervous system (CNS) are organized into structures with appropriate size and shape is still unclear. We report that in the absence of the mouse transcription factor mBtd/Sp8, a posterior shift of the isthmic organizer(IsO) occurs, suggesting a crucial role for Sp8 in this process...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (14): 3209–3216.
Published: 15 July 2005
... ) 13 5 2005 ©2005. 2005 Midbrain-hindbrain boundary Isthmic organizer Lineage restriction Neuromeres segments Zebrafish Mesencephalon Metencephalon otx2 gbx1 fgf8 The developing central nervous system is compartmentalized at the neural tube stage into discrete...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2003) 130 (22): 5331–5338.
Published: 15 November 2003
...Paula Alexandre; Marion Wassef During vertebrate development, an organizing signaling center, the isthmic organizer, forms at the boundary between the midbrain and hindbrain. This organizer locally controls growth and patterning along the anteroposterior axis of the neural tube. On the basis of...
Journal Articles
Journal: Development
Development (2003) 130 (12): 2633–2644.
Published: 15 June 2003
...), respectively. Development of the mes and met is thought to be regulated by molecules produced by a signaling center, termed the isthmic organizer (IsO),which is localized at the boundary between them. FGF8 and WNT1 have been implicated as key components of IsO signaling activity, and previous studies have...