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Keywords: Isthmic organizer
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Journal Articles
Journal:
Development
Development (2008) 135 (12): 2093–2103.
Published: 15 June 2008
... 133 , 517 -528. Chenn, A. and Walsh, C. A. ( 2002 ). Regulation of cerebral cortical size by control of cell cycle exit in neural precursors. Science 297 , 365 -369. Chi, C. L., Martinez, S., Wurst, W. and Martin, G. R. ( 2003 ). The isthmic organizer signal FGF8 is required for cell...
Includes: Supplementary data
Journal Articles
Chao Guo, Hai-Yan Qiu, Ying Huang, Haixu Chen, Rong-Qiang Yang, Sheng-Di Chen, Randy L. Johnson, Zhou-Feng Chen, Yu-Qiang Ding
Journal:
Development
Development (2007) 134 (2): 317–325.
Published: 15 January 2007
... expression of Fgf8, Wnt1 and several isthmus-related transcription factors in the MHB, and is a crucial component of a cross-regulatory network required for the induction activity of the isthmic organizer in the MHB. In the wild-type embryo, Fgf8 expression was first observed in the presumptive MHB...
Journal Articles
Victor V. Chizhikov, Anne G. Lindgren, D. Spencer Currle, Matthew F. Rose, Edwin S. Monuki, Kathleen J. Millen
Journal:
Development
Development (2006) 133 (15): 2793–2804.
Published: 1 August 2006
...Victor V. Chizhikov; Anne G. Lindgren; D. Spencer Currle; Matthew F. Rose; Edwin S. Monuki; Kathleen J. Millen During embryogenesis, the isthmic organizer, a well-described signaling center at the junction of the mid-hindbrain, establishes the cerebellar territory along the anterior/posterior axis...
Includes: Supplementary data
Journal Articles
Positive and negative regulations by FGF8 contribute to midbrain roof plate developmental plasticity
Journal:
Development
Development (2006) 133 (15): 2905–2913.
Published: 1 August 2006
... to M.W. P.A. was supported by fellowships from FCT, Fondation des Treilles and FRM, and I.B. was supported by ARC. References Adams, K. A., Maida, J. M., Golden, J. A. and Riddle, R. D. ( 2000 ). The transcription factor Lmx1b maintains Wnt1 expression within the isthmic organizer. Development...
Journal Articles
Gundula Griesel, Dieter Treichel, Patrick Collombat, Jens Krull, Andreas Zembrzycki, Willem M. R. van den Akker, Peter Gruss, Antonio Simeone, Ahmed Mansouri
Journal:
Development
Development (2006) 133 (9): 1779–1787.
Published: 1 May 2006
... territories of the central nervous system (CNS) are organized into structures with appropriate size and shape is still unclear. We report that in the absence of the mouse transcription factor mBtd/Sp8, a posterior shift of the isthmic organizer(IsO) occurs, suggesting a crucial role for Sp8 in this process...
Includes: Supplementary data
Journal Articles
Journal:
Development
Development (2005) 132 (14): 3209–3216.
Published: 15 July 2005
... boundary. Our conclusions are based on the following results. * Author for correspondence (e-mail: [email protected] ) 13 5 2005 ©2005. 2005 Midbrain-hindbrain boundary Isthmic organizer Lineage restriction Neuromeres segments Zebrafish Mesencephalon Metencephalon otx2...
Includes: Multimedia, Supplementary data
Journal Articles
Journal:
Development
Development (2003) 130 (22): 5331–5338.
Published: 15 November 2003
...Paula Alexandre; Marion Wassef During vertebrate development, an organizing signaling center, the isthmic organizer, forms at the boundary between the midbrain and hindbrain. This organizer locally controls growth and patterning along the anteroposterior axis of the neural tube. On the basis...
Journal Articles
Journal:
Development
Development (2003) 130 (12): 2633–2644.
Published: 15 June 2003
...), respectively. Development of the mes and met is thought to be regulated by molecules produced by a signaling center, termed the isthmic organizer (IsO),which is localized at the boundary between them. FGF8 and WNT1 have been implicated as key components of IsO signaling activity, and previous studies have...
Journal Articles
Journal:
Development
Development (1999) 126 (6): 1189–1200.
Published: 15 March 1999
... between the prospective midbrain and hindbrain. This ectopic isthmic organizer apparently sends long-range patterning signals both rostrally and caudally, resulting in the development of the two ectopic midbrains. Interestingly, our data suggest that these inductive signals spread readily in a caudal...
Journal Articles
Journal:
Development
Development (1997) 124 (18): 3639–3650.
Published: 15 September 1997
... these findings support the existence of a molecular mechanism depending on a precise threshold of OTX proteins that is required to specify early regional diversity between adjacent mes-met territories and, in turn, to allow the correct positioning of the isthmic organizer. In fact, (i) Otx genes...