... of stromal adipocytes. This highly regulated involution process is associated with a transient increased risk of breast cancer in women. Using a syngeneic tumour model, we show that tumour growth is significantly altered depending on the stage of involution at which tumour cells are implanted. Tumour cells...

... involution at the Xenopus dorsal blastopore lip. We show that a phase of rapid involution – peak involution – is intimately linked to an early stage of convergent extension, which involves differential cell migration in the prechordal mesoderm and a new movement of the chordamesoderm, radial convergence...

...Muthusamy Thangaraju; Martina Rudelius; Brian Bierie; Mark Raffeld; Shikha Sharan; Lothar Hennighausen; A-Mei Huang; Esta Sterneck The STAT3 transcription factor is an important initiator of mammary gland involution in the mouse. This work shows that the STAT3 target gene CCAAT/enhancer binding...

...Elizabeth Tonner; Michael C. Barber; Gordon J. Allan; James Beattie; John Webster; C. Bruce A. Whitelaw; David J. Flint We have previously demonstrated that IGFBP-5 production by mammary epithelial cells increases dramatically during involution of the mammary gland. To demonstrate a causal...

... epithelia from nulliparous versus parous females to hormonal stimulation and carcinogenic agents. We present genetic evidence that an involuted mammary gland is fundamentally different from a virgin gland, despite its close morphological resemblance. This difference results from the formation of a new...

... had earlier been labeled by fluorescent dye injection into the middle region of the DML, a site that maximizes the potential to discriminate among experimental outcomes. Double-dye injection experiments conducted at this site demonstrate that cells fated to form myotome do not involute around...

...Andrew V. Nguyen; Jeffrey W. Pollard ABSTRACT Involution of the mammary gland following weaning is divided into two distinct phases. Initially, milk stasis results in the induction of local factors that cause apoptosis in the alveolar epithelium. Secondly after a prolonged absence of suckling...

... , an active distortion of the vegetal cell mass, vegetal rotation, leads to a dramatic expansion of the blastocoel floor and a concomitant turning around of the marginal zone which constitutes the first and major step of mesoderm involution. This vigorous inward surging of the vegetal region...

...Leif R. Lund; John Rømer; Nicole Thomasset; Helene Solberg; Charles Pyke; Mina J. Bissell; Keld Danø; Zena Werb ABSTRACT Postlactational involution of the mammary gland is characterized by two distinct physiological events: apoptosis of the secretory, epithelial cells undergoing programmed cell...

... are generally more extensive than those of EVL cells present at the same location in the early gastrula. In the case of C the DEL cells also involute. Except for involution (see Warga and Kimmel, 1990 ), the movements are generally very similar to those described by Ballard in other teleosts ( Ballard, 1981...

...) Radial cell intercalations during epiboly mix cells located deeply in the blastoderm among more superficial ones. These rearrangements thoroughly stir the positions of deep cells, as the blastoderm thins and spreads across the yolk cell. (2) Involution at or near the blastoderm margin occurs during...