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Keywords: Intraflagellar transport
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Journal Articles
Journal: Development
Development (2017) 144 (8): 1544–1553.
Published: 15 April 2017
...Daisy Xin; Kasey J. Christopher; Lewie Zeng; Yong Kong; Scott D. Weatherbee Cilia are key regulators of animal development and depend on intraflagellar transport (IFT) proteins for their formation and function, yet the roles of individual IFT proteins remain unclear. We examined the Ift56 hop mouse...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (12): 2194–2202.
Published: 15 June 2015
..., we characterized the function of Ift27 , which encodes a subunit of intraflagellar transport (IFT) complex B. Hair follicle morphogenesis of Ift27 -null mice was severely impaired, reminiscent of phenotypes observed in cilia and Hh mutants. Furthermore, the Hh signaling pathway was attenuated...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (6): 897–903.
Published: 15 March 2009
.... We show that in mice mutant for a cilia intraflagellar transport (IFT) protein, IFT88/polaris, Shh activity is increased in the toothless diastema mesenchyme of the embryonic jaw primordia. This results in the formation of ectopic teeth in the diastema, mesial to the first molars. This phenotype...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (23): 5329–5339.
Published: 01 December 2005
... called intraflagellar transport (IFT). Mutations in IFT genes, such as Tg737 , result in severe developmental defects and disease. In the case of the Tg737 orpk mutants, these pathological alterations include cystic kidney disease, biliary and pancreatic duct abnormalities, skeletal patterning defects...
Includes: Multimedia, Supplementary data