...Joseph Lee; Antoine Gleizes; Nicolas V. Janto; Lito L. Appell; Siyang Sun; Felipe Takaesu; Sarah F. Webster; Taylor Hailstock; Nick Barker; Adam D. Gracz ABSTRACT Progenitors and mature cells can maintain the intestinal epithelium by dedifferentiation and facultative intestinal stem cell (fISC...

... major lipid metabolic pathways: the build-up of lipids, called de novo lipogenesis, and the breakdown of lipids, called fatty acid beta-oxidation. We cover the recent literature on hematopoietic stem cells, intestinal stem cells, neural stem/progenitor cells and cancer stem cells, where these two lipid...

... of intestinal crypt cell proliferation. Despite increasing data, in-depth analysis on their specific action on intestinal stem cells is lacking. By using ex vivo 3D organoid cultures and molecular approaches, we observed early responses to T3 involving the T3-metabolizing enzyme Dio1 and the transporter Mct10...

... Niche Germline stem cells Somatic stem cells Testis Intestine Intestinal stem cells Enterocytes Wing disc Cytokines Proliferation Survival Differentiation Cell competition Niche competition Inflammation Regeneration Cellular plasticity Cell reprogramming In the early 1990s...

... symmetric signalling states. We apply this model to the adult intestinal stem cell (ISC) of Drosophila , the fate of which is stochastic but dependent on the Notch/Delta pathway. We observe a correlation between signalling state in cell pairs and their contact area. We interpret this behaviour in terms...

...Narges Aghaallaei; Franziska Gruhl; Colin Q. Schaefer; Tobias Wernet; Venera Weinhardt; Lázaro Centanin; Felix Loosli; Tilo Baumbach; Joachim Wittbrodt Recently, a stochastic model of symmetrical stem cell division followed by neutral drift has been proposed for intestinal stem cells (ISCs), which...

... pathways results in the loss of the intestinal stem cells (ISCs). However, whether the effect of Notch is direct or due to the aberrant differentiation of the transit-amplifying cells into post-mitotic goblet cells is unknown. To address this issue, we have generated composite tamoxifen-inducible intestine...

... dispatched between the two daughters upon stem cell mitosis. In the adult Drosophila midgut, the intestinal stem cell (ISC) divides to generate a new ISC and an enteroblast (EB) differentiating daughter. Notch signalling activity restricted to the EB regulates intestinal cell fate decision. Here, we show...

.... In a screen for genes that regulate cell lineage determination in the posterior midgut, we identified that the Osa-containing SWI/SNF (Brahma) chromatin-remodeling complex regulates Drosophila midgut homeostasis. Mutations in subunits of the Osa-containing complex result in intestinal stem cell (ISC...

... Drosophila midgut as a model system to investigate the molecular events that mediate intestinal hyperplasia following loss of Apc in the intestine. Our results indicate that the conserved Wnt target Myc and its binding partner Max are required for the initiation and maintenance of intestinal stem cell (ISC...

...Xiankun Zeng; Steven X. Hou Like the mammalian intestine, the Drosophila adult midgut is constantly replenished by multipotent intestinal stem cells (ISCs). Although it is well known that adult ISCs arise from adult midgut progenitors (AMPs), relatively little is known about the mechanisms...

...Benoît Biteau; Heinrich Jasper Precise control of somatic stem cell proliferation is crucial to ensure maintenance of tissue homeostasis in high-turnover tissues. In Drosophila , intestinal stem cells (ISCs) are essential for homeostatic turnover of the intestinal epithelium and ensure epithelial...

...Rachael L. Shaw; Alexander Kohlmaier; Cédric Polesello; Cornelia Veelken; Bruce A. Edgar; Nicolas Tapon Intestinal stem cells (ISCs) in the adult Drosophila midgut proliferate to self-renew and to produce differentiating daughter cells that replace those lost as part of normal gut function...

... by a population of multipotent intestinal stem cells (ISCs) that resides in epithelial niches. Adenomatous polyposis coli ( Apc ), a tumor suppressor gene conserved in both invertebrates and vertebrates, is known to play a role in multiple developmental processes in Drosophila . Here, we examine the consequences...

... Intestinal stem cells All metazoan embryos develop an inner gut cavity for the general purpose of nutrient absorption and gas exchange. The gut is lined by an endodermal epithelium and surrounded by mesenchymal cells in triploblastic animals, and has achieved a sophisticated level of patterning...