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Keywords: Intestinal stem cells
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Journal Articles
Journal: Development
Development (2021) 148 (8): dev194357.
Published: 20 April 2021
... of intestinal crypt cell proliferation. Despite increasing data, in-depth analysis on their specific action on intestinal stem cells is lacking. By using ex vivo 3D organoid cultures and molecular approaches, we observed early responses to T3 involving the T3-metabolizing enzyme Dio1 and the...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (2): dev167643.
Published: 29 January 2019
... Niche Germline stem cells Somatic stem cells Testis Intestine Intestinal stem cells Enterocytes Wing disc Cytokines Proliferation Survival Differentiation Cell competition Niche competition Inflammation Regeneration Cellular plasticity Cell reprogramming In the early 1990s...
Journal Articles
Journal: Development
Development (2017) 144 (7): 1177–1186.
Published: 01 April 2017
... symmetric signalling states. We apply this model to the adult intestinal stem cell (ISC) of Drosophila , the fate of which is stochastic but dependent on the Notch/Delta pathway. We observe a correlation between signalling state in cell pairs and their contact area. We interpret this behaviour in terms of...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (19): 3470–3480.
Published: 01 October 2016
...Narges Aghaallaei; Franziska Gruhl; Colin Q. Schaefer; Tobias Wernet; Venera Weinhardt; Lázaro Centanin; Felix Loosli; Tilo Baumbach; Joachim Wittbrodt Recently, a stochastic model of symmetrical stem cell division followed by neutral drift has been proposed for intestinal stem cells (ISCs), which...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (1): 41–50.
Published: 01 January 2015
... pathways results in the loss of the intestinal stem cells (ISCs). However, whether the effect of Notch is direct or due to the aberrant differentiation of the transit-amplifying cells into post-mitotic goblet cells is unknown. To address this issue, we have generated composite tamoxifen-inducible intestine...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (10): 2014–2023.
Published: 15 May 2014
... dispatched between the two daughters upon stem cell mitosis. In the adult Drosophila midgut, the intestinal stem cell (ISC) divides to generate a new ISC and an enteroblast (EB) differentiating daughter. Notch signalling activity restricted to the EB regulates intestinal cell fate decision. Here, we show...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (17): 3532–3540.
Published: 01 September 2013
... a screen for genes that regulate cell lineage determination in the posterior midgut, we identified that the Osa-containing SWI/SNF (Brahma) chromatin-remodeling complex regulates Drosophila midgut homeostasis. Mutations in subunits of the Osa-containing complex result in intestinal stem cell (ISC...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (24): 4524–4535.
Published: 15 December 2012
... Drosophila midgut as a model system to investigate the molecular events that mediate intestinal hyperplasia following loss of Apc in the intestine. Our results indicate that the conserved Wnt target Myc and its binding partner Max are required for the initiation and maintenance of intestinal stem cell (ISC...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (21): 3917–3925.
Published: 01 November 2012
...Xiankun Zeng; Steven X. Hou Like the mammalian intestine, the Drosophila adult midgut is constantly replenished by multipotent intestinal stem cells (ISCs). Although it is well known that adult ISCs arise from adult midgut progenitors (AMPs), relatively little is known about the mechanisms that...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (6): 1045–1055.
Published: 15 March 2011
...Benoît Biteau; Heinrich Jasper Precise control of somatic stem cell proliferation is crucial to ensure maintenance of tissue homeostasis in high-turnover tissues. In Drosophila , intestinal stem cells (ISCs) are essential for homeostatic turnover of the intestinal epithelium and ensure epithelial...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (24): 4147–4158.
Published: 15 December 2010
...Rachael L. Shaw; Alexander Kohlmaier; Cédric Polesello; Cornelia Veelken; Bruce A. Edgar; Nicolas Tapon Intestinal stem cells (ISCs) in the adult Drosophila midgut proliferate to self-renew and to produce differentiating daughter cells that replace those lost as part of normal gut function...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (13): 2255–2264.
Published: 01 July 2009
... a population of multipotent intestinal stem cells (ISCs) that resides in epithelial niches. Adenomatous polyposis coli ( Apc ), a tumor suppressor gene conserved in both invertebrates and vertebrates, is known to play a role in multiple developmental processes in Drosophila . Here, we examine the...
Includes: Supplementary data