.... A similar phenomenon is found in intestinal stem cells (ISCs), except that HSD disrupts ISC maintenance and differentiation. Interestingly, tumor-like GSCs and ISCs are less responsive to HSD, which may be because of their dependence on glycolytic metabolism and high energy demand, respectively. This study...

... diseases. However, how endogenous factors influence the proliferation and differentiation of intestinal stem cells (ISCs) under physiological and pathological conditions remains poorly understood. Here, we find that the evolutionarily conserved endoplasmic reticulum membrane protein complex (EMC...

... that colonic recovery from colitis-like injury depends on multiple Wnt-producing sources. Wntless Wnt Tagln Acta2 Gpr177 Colitis Wound healing Intestinal stem cell National Institutes of Health R01DK102934 R01DE026936 R01DE015654 R01DK119198 R01AT010243 American Cancer...

.... , Siudeja , K. , Perdigoto , C. N. , Boumard , B. , Gervais , L. , Gillet-Markowska , A. , Al Zouabi , L. , Schweisguth , F. and Bardin , A. J. ( 2018 ). Spen limits intestinal stem cell self-renewal . PLoS Genet. 14 , e1007773 . 10.1371/journal.pgen.1007773...

...Gaigai Wei; Na Gao; Jiwei Chen; Lingling Fan; Zhiyang Zeng; Ganglong Gao; Liang Li; Guojiu Fang; Kewen Hu; Xiufeng Pang; Heng-Yu Fan; Hans Clevers; Mingyao Liu; Xueli Zhang; Dali Li ABSTRACT Homeostasis of intestinal stem cells (ISCs) is maintained by the orchestration of niche factors...

...Anna Baulies; Nikolaos Angelis; Vivian S. W. Li ABSTRACT Intestinal stem cells (ISCs) are highly proliferative cells that fuel the continuous renewal of the intestinal epithelium. Understanding their regulatory mechanisms during tissue homeostasis is key to delineating their roles in development...

...Jesse R. Raab; Deepthi Y. Tulasi; Kortney E. Wager; Jeremy M. Morowitz; Scott T. Magness; Adam D. Gracz ABSTRACT Intestinal stem cell (ISC) plasticity is thought to be regulated by broadly permissive chromatin shared between ISCs and their progeny. Here, we have used a Sox9 EGFP reporter to examine...

... organ-boundary intestinal stem cells (OB-ISCs) is regulated by the neighboring hindgut, a developmentally distinct organ. This distinct OB-ISC control occurs through proximity to a specialized transition zone between the endodermal midgut and ectodermal hindgut that shares molecular signatures of both...

... enriched in adult intestinal stem cells in the Drosophila intestine. lin-28 null mutants are homozygous viable but display defects in this population of cells, which fail to undergo a characteristic food-triggered expansion in number and have reduced rates of symmetric division as well as reduced insulin...

...Chenhui Wang; Xingting Guo; Kun Dou; Hongyan Chen; Rongwen Xi In adult Drosophila midgut, intestinal stem cells (ISCs) periodically produce progenitor cells that undergo a binary fate choice determined primarily by the levels of Notch activity that they receive, before terminally differentiating...

.... Biol. Chem. 285 , 20369 - 20380 . 10.1074/jbc.M109.081521 Durand , A. , Donahue , B. , Peignon , G. , Letourneur , F. , Cagnard , N. , Slomianny , C. , Perret , C. , Shroyer , N. F. and Romagnolo , B. ( 2012 ). Functional intestinal stem cells after...

...Xiankun Zeng; Steven X. Hou Functional mature cells are continually replenished by stem cells to maintain tissue homoeostasis. In the adult Drosophila posterior midgut, both terminally differentiated enterocyte (EC) and enteroendocrine (EE) cells are generated from an intestinal stem cell (ISC...

... A. , Jiang J. , Ip Y. T. ( 2009 ). Tissue damage-induced intestinal stem cell division in Drosophila . Cell Stem Cell 4 , 49 – 61 . Artavanis-Tsakonas S. , Muskavitch M. A. ( 2010 ). Notch: the past, the present, and the future . Curr. Top. Dev. Biol. 92 , 1 – 29...

... indicates tumor progression driven by the tumor environment . Proc. Natl. Acad. Sci. USA 98 , 10356 – 10361 . Fevr T. , Robine S. , Louvard D. , Huelsken J. ( 2007 ). Wnt/beta-catenin is essential for intestinal homeostasis and maintenance of intestinal stem cells . Mol...

... for the Hippo pathway in SCs, and have implications for understanding the role of this pathway in tumorigenesis and cancer stem cells. References Amcheslavsky A. , Jiang J. , Ip Y. T. ( 2009 ). Tissue damage-induced intestinal stem cell division in Drosophila . Cell Stem Cell 4...