... medium provided that the original work is properly attributed. Summary: Regeneration of the intestinal epithelium relies on a hierarchical stem cell model involving a previously unreported lineage of reserve stem cells in addition to the plasticity model. Intestinal development Organoids...

..., at least in the context of intestinal development and homeostasis. Processing by extracellular proteases is generally assumed to impede normal biological function of EpCAM. Indeed, cleavage within the TY loop that contains the dibasic site Arg80-Arg81 was shown to prevent EpCAM dimerization...

...Miao-Lin Li; Si-Yi Cao; Jia Qu; Lei Zhang; Qiang Gao; Xu Wang; Miao Yin; Ying Liu; Ming-Zhu Lei; Qun-Ying Lei ABSTRACT Methionine is important for intestinal development and homeostasis in various organisms. However, the underlying mechanisms are poorly understood. Here, we demonstrate...

... that overactivation of the membrane-anchored serine protease matriptase in the absence of its inhibitor HAI-2 triggers intestinal failure. Intestinal development Enteropathy Membrane-anchored serine protease Epithelial barrier EpCAM HAI-2 Congenital tufting enteropathy (CTE, OMIM #613217...

... , 783 - 794 . 10.1387/ijdb.072493rb Coulombre , A. J. and Coulombre , J. L. (1958). Intestinal development. I. Morphogenesis of the villi and musculature . J. Embryol. Exp. Morphol.   6 , 403 - 411 . de Castro , A. M. M. G. , Alvares , E. P. , Zocoller-Seno , M. C...

... Thomas’s Hospital, United Medical and Dental Schools, Lambeth Palace Road, London SEI 7EH, UK 30 09 1991 © 1992 by Company of Biologists 1992 intestinal development epithelial-mesenchymal interactions xenograft collagen The study of the mechanisms underlying developmental...