... embryonic progenitor cells that are fated towards inhibitory interneurons. We quantified relevant cell populations during embryonic inhibitory neuron specification and found an increase in the proliferation of Nkx2.1 + interneuron progenitors in the embryonic medial ganglionic eminence at E14...

... of dendritic architecture in the embryonic brain. Reelin expression switches postnatally from Cajal-Retzius cells to interneurons. However, reelin function in interneuron development is still poorly understood. Here, we have investigated the role of reelin in interneuron development in the postnatal neocortex...

...Jia Sheng Hu; Daniel Vogt; Susan Lindtner; Magnus Sandberg; Shanni N. Silberberg; John L. R. Rubenstein Distinct cortical interneuron (CIN) subtypes have unique circuit functions; dysfunction in specific subtypes is implicated in neuropsychiatric disorders. Somatostatin- and parvalbumin-expressing...

... cells, which in turn generate neuroblasts that migrate along the rostral migratory stream (RMS) to the olfactory bulb (OB). Here, we have examined the role of the COUP-TFI and COUP-TFII orphan nuclear receptor transcription factors in mouse OB interneuron development. We observed that COUP-TFI...

..., neurosecretory cells and interneurons). We found neuronal, but not glial, nuclei occupied stereotyped locations. We added 75 new Gal4 markers to the atlas to identify over 50% of all interneurons in the ventral CNS, and these lines allowed functional access to those interneurons for the first time. We expect...

... in development (10-15 DIV), the type I TARPs γ-2, γ-3 and γ-8 promote dendritic growth, whereas γ-4 reduced dendritic growth. The type II TARPs failed to alter dendritic morphology. The TARP-induced dendritic growth was restricted to the apical dendrites of pyramidal cells and it did not affect interneurons...

... of dorsal interneurons: dI1-dI3-dI5. Analysis of the BMP7 mouse mutant shows the conservation of this activity in mammals. Furthermore, this BMP7 activity appears to be mediated by the canonical Smad pathway, as we demonstrate that Smad1 and Smad5 activities are similarly required for the generation of dI1...

...Kaia Skaggs; Donna M. Martin; Bennett G. Novitch The neural circuits that control motor activities depend on the spatially and temporally ordered generation of distinct classes of spinal interneurons. Despite the importance of these interneurons, the mechanisms underlying their genesis are poorly...

... declare no competing financial interests. 23 2 2011 © 2011. 2011 Cadherin Neural tube Chick RNAi Screen FatJ Progenitor cells Interneurons Phenotype Hippo pathway Notch signalling Morphogen Neural progenitor cells are patterned along the dorsoventral axis...

... similar patterns of expression to their mammalian homologues during late development. However, they are also expressed from early neurula stages in an intermediate region of the open neural plate where primary interneurons form. The Gsx homologue in the protostome Drosophila is expressed...

...Angelo Iulianella; Madhulika Sharma; Greg B. Vanden Heuvel; Paul A. Trainor Obtaining the diversity of interneuron subtypes in their appropriate numbers requires the orchestrated integration of progenitor proliferation with the regulation of differentiation. Here we demonstrate through loss...

...Tuhina Prasad; Xiaozhong Wang; Paul A. Gray; Joshua A. Weiner Although the role of developmental apoptosis in shaping the complement and connectivity of sensory and motoneurons is well documented, the extent to which cell death affects the 13 cardinal classes of spinal interneurons is unclear...

... development as well as in neuroblast and interneuron differentiation. These defects correlate with reduced cell-cycle progression of neural progenitors coupled with diminished Neurod and p27 Kip1 activity. Conversely, in Cux2 gain-of-function transgenic mice, the spinal cord is enlarged in association...

... spinal cord precursors called pMN cells produce mostly motoneurons and oligodendrocytes, but recent lineage-marking experiments reveal that they also make astrocytes, ependymal cells and interneurons. Our own clonal analysis of pMN cells in zebrafish showed that some produce a primary motoneuron and KA...

... the expression of neurogenic factors and the cyclin-dependent-kinase-inhibitor p27 kip1 . Furthermore, Smad3 activity induces differentiation of selected neuronal subtypes at the expense of other subtypes. Within the intermediate and ventral domains, Smad3 promotes differentiation of ventral interneurons...

...Eva Vergaño-Vera; María J. Yusta-Boyo; Fernando de Castro; Antonio Bernad; Flora de Pablo; Carlos Vicario-Abejón During the embryonic period, many olfactory bulb (OB) interneurons arise in the lateral ganglionic eminence (LGE) from precursor cells expressing Dlx2,Gsh2 and Er81 transcription...

...Sonja Kriks; Guillermo M. Lanuza; Rumiko Mizuguchi; Masato Nakafuku; Martyn Goulding The molecular programs that specify progenitors in the dorsal spinal cord remain poorly defined. The homeodomain transcription factor Gsh2 is expressed in the progenitors of three dorsal interneuron subtypes, dI3...

.... In the absence of Nkx6.1, there are fewer secondary motoneurons and supernumerary ventral interneurons, suggesting Nkx6.1 promotes motoneuron and suppresses interneuron formation. Overexpression of fish or fly Nkx6 is sufficient to generate supernumerary motoneurons in both zebrafish and flies. These results...

..., 10900 Euclid Avenue, Cleveland, Ohio 44106,USA † These authors contributed equally to this work 11 8 2004 © 2004. 2004 Drosophila melanogaster Neuronal fate specification Motoneurons Interneurons Axon outgrowth Nkx6 hb9 (exex) lim3 islet eve vnd...

...-mail: [email protected] ) 18 4 2002 © 2002. 2002 Neocortex Cortical lamination Radial cell migration Tangential cell migration Emx1 Emx2 Cajal-Retzius cells Subplate neurons Pioneer neurons Interneurons Ganglionic eminence Mouse The mammalian cortex is the most...