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Development (2015) 142 (4): 672–680.
Published: 15 February 2015
.... Interestingly, prior to the onset of PCD, the autopod vasculature undergoes extensive patterning that results in high interdigital vascularity. Here, we show that in mice, the limb vasculature positively regulates interdigital PCD. In vivo , reduction in interdigital vessel number inhibited PCD, resulting...
Development (2007) 134 (12): 2359–2368.
Published: 15 June 2007
...Sangeeta Pajni-Underwood; Catherine P. Wilson; Cindy Elder; Yuji Mishina; Mark Lewandoski In vertebrate limbs that lack webbing, the embryonic interdigit region is removed by programmed cell death (PCD). Established models suggest that bone morphogenetic proteins (BMPs) directly trigger such PCD...