... endothelial-fibronectin interactions in FGR are a key mechanism underlying impaired FGR endothelial migration. Using human fetoplacental endothelial cells isolated from uncomplicated term control and FGR pregnancies, we assessed integrin α5β1 and αvβ3 regulation during cell migration. We show that endothelial...

... and subcellular distribution of progenitor cell integrins, supporting symmetric divisions that expand intestinal stem cell populations. Collectively, our data emphasize the impact of commensal microbes on division and maintenance of the intestinal progenitor compartment. * These authors contributed equally...

... migration, cells undergo cycles of coordinated attachment and detachment from the extracellular matrix (ECM). Embryonic migration processes that require cell-ECM attachment are dependent on the integrin family of adhesion receptors. Precise regulation of integrin-mediated adhesion is important for many...

...Holly E. Lovegrove; Dan T. Bergstralh; Daniel St Johnston ABSTRACT The Drosophila egg chamber comprises a germline cyst surrounded by a tightly organised epithelial monolayer, the follicular epithelium (FE) . Loss of integrin function from the FE disrupts epithelial organisation at egg chamber...

... and the restriction of these processes once regeneration is complete. In planarians, flatworms with high regenerative potential, muscle cells express some of these instructive cues. Here, we show that members of the integrin family of adhesion molecules are required for the integrity of regenerating tissues...

... integrin α v β 3 on basal progenitors in embryonic mouse neocortex promotes their expansion. Specifically, integrin α v β 3 activation causes an increased cell cycle re-entry of Pax6-negative, Tbr2-positive intermediate progenitors, rather than basal radial glia, and a decrease in the proportion...

... astrocyte differentiation. The addition of exogenous laminins to laminin-null retinal explants rescues astrocyte migration and spatial patterning. Furthermore, we show that the loss of laminins reduces β1 integrin expression in astrocytes. Culturing laminin-null retinal astrocytes on laminin substrates...

... by laminin 211, or glycosylated by Large and fukutin during sorting. Candidates are αβ1 integrins, because their absence phenocopies laminin and glycosyltransferase deficiency, but the topography of the phenotypes is different and β1 integrins are not substrates for Large and fukutin. By contrast, deletion...

... and pathogenic damage and from changes in the ionic environment. Integrins, a major family of ECM receptors, play a number of roles in the development of myelinating Schwann cells, one class of glia ensheathing the peripheral nerves of vertebrates. However, the identity and the role of the integrin complexes...

...Yingjie Liu; Nibedita Chattopadhyay; Shan Qin; Charles Szekeres; Tetyana Vasylyeva; Zhen X. Mahoney; Mary Taglienti; Carlton M. Bates; Harold A. Chapman; Jeffrey H. Miner; Jordan A. Kreidberg Integrin receptors for the extracellular matrix and receptor tyrosine kinase growth factor receptors...

... to interact not only with Grip but also with multiple edematous wings , which encodes one subunit of the αPS1-βPS integrin expressed in tendon cells. These experiments uncovered a previously unrecognized role for the αPS1-βPS integrin in the formation of muscle projections during early stages of myotendinous...

..., ectoderm is the major producer of fibronectin ( Fn1 ) transcripts, whereas all but the anterior-most region of the PSM expresses the fibronectin assembly receptor, integrinα5 ( Itga5 ). We thus propose that the ectoderm-derived fibronectin is assembled by mesodermal α5β1 integrin on the surface of the PSM...

...Caroline Grabbe; Christos G. Zervas; Tony Hunter; Nicholas H. Brown; Ruth H. Palmer The mammalian focal adhesion kinase (FAK) family of non-receptor protein-tyrosine kinases has been implicated in controlling a multitude of cellular responses to the engagement of cell-surface integrins and G...

...Kathleen A. Clark; Maura McGrail; Mary C. Beckerle Integrins play a crucial role in cell motility, cell proliferation and cell survival. The evolutionarily conserved LIM protein PINCH is postulated to act as part of an integrin-dependent signaling complex. In order to evaluate the role of PINCH...

... of vascular defects around E11.5 due to haemorrhage and vascular integrity defects. Vascular supporting cells did not develop appropriately. C3G-deficient fibroblasts responded to PDGF-BB abnormally, exhibited cell adhesion defects and lacked paxillin and integrin-β1-positive cell adhesions. In contrast...

...Xitong Li; Michael W. Graner; Erin L. Williams; Carol E. Roote; Thomas A. Bunch; Susan Zusman ABSTRACT The integrins are a family of transmembrane heterodimeric proteins that mediate adhesive interactions and participate in signaling across the plasma membrane. In this study we examine...

...Marc C. Brabant; Dianne Fristrom; Thomas A. Bunch; Danny L. Brower ABSTRACT At the onset of pupariation in the Drosophila wing, the PS1 and PS2 integrins are expressed preferentially on the dorsal and ventral wing epithelia, respectively. Clonal analysis experiments have indicated that integrins...

... of the integrins, are required for epithelial morphogenesis during proventriculus development. In contrast, this morphogenetic process is suppressed by the decapentaplegic gene, which encodes a member of the TGFβ family of growth factors. These results identify a novel cell signaling center in the foregut...

... is trophoblast invasion of the uterine wall. Previous studies have shown that differentiation of trophoblasts to an invasive phenotype is accompanied by temporally and spatially regulated switching of their integrin repertoire. In the first trimester human placenta, α6 integrins are restricted to cytotrophoblast...

...Muriel Delannet; Fabrice Martin; Blaise Bossy; David A. Cheresh; Louis F. Reichardt; Jean-Loup Duband ABSTRACT To identify potentially important extracellular matrix adhesive molecules in neural crest cell migration, the possible role of vitronectin and its corresponding integrin receptors...