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Keywords: Integrin
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Journal Articles
Journal: Development
Development (2022) 149 (10): dev200647.
Published: 19 May 2022
.... Cell Biol. 17 , 1597 - 1606 . 10.1038/ncb3268 Bachir , A. I. , Zareno , J. , Moissoglu , K. , Plow , E. F. , Gratton , E. and Horwitz , A. R. ( 2014 ). Integrin-associated complexes form hierarchically with variable stoichiometry in nascent adhesions . Curr...
Journal Articles
Journal: Development
Development (2020) 147 (5): dev184713.
Published: 11 March 2020
...://www.biologists.com/user-licence-1-1/ Highlighted Article: Wingless signaling activity controls cell shape and mechanical tension to guide the morphogenesis of Drosophila wing discs. Epithelial folding Mechanical tension Integrin Wnt/Wingless Wing disc Drosophila Animals undergo...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (4): dev181552.
Published: 17 February 2020
...Mathilde Romagnoli; Laura Bresson; Amandine Di-Cicco; María Pérez-Lanzón; Patricia Legoix; Sylvain Baulande; Pierre de la Grange; Adèle De Arcangelis; Elisabeth Georges-Labouesse; Arnoud Sonnenberg; Marie-Ange Deugnier; Marina A. Glukhova; Marisa M. Faraldo ABSTRACT Integrin dimers α3/β1, α6/β1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (16): dev172668.
Published: 29 August 2019
... progenitors in a proliferative state via integrins α6β1 and α7β1, whereas low concentrations of lm211 support mDA lineage survival via dystroglycan receptors. We confirmed our findings in vivo , demonstrating that the VM was smaller in the absence of lm-α2, with increased apoptosis; furthermore...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (14): dev177295.
Published: 16 July 2019
... TVM morphogenesis; however, the inverse, supplying FGF to the TVM, does not rescue CVM mismigration. In addition, we show that FGF regulates integrin expression in both tissues, but only providing a source of integrin specifically to the TVM attenuates the contralateral merging phenotype. Finally, we...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (2): dev166454.
Published: 16 January 2019
.../ Highlighted Article: Inactivation of the Hippo pathway (nuclear Yap) or ablation of Yap result in increased β-catenin and Fgf10 signaling, suggesting a cytoplasmic role for Yap in epithelial lineage commitment. Lung Hippo Yap Fgfr2 Ilk Fgf10 Integrin β-Catenin Differentiation Progenitor...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (19): dev161927.
Published: 1 October 2018
... transition (MET). FGF activity leads to accumulation of β-integrin Myospheroid basally and cell polarity factor Bazooka apically within mesoderm cells, thereby reestablishing apicobasal cell polarity in an epithelialized state in which cells express both E-Cadherin and N-Cadherin. In summary, FGF plays...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (13): dev162651.
Published: 5 July 2018
... that a fibronectin-integrin-syndecan module acts between p21-activated kinase 1 upstream and ephrin B1 downstream to promote the contact-induced collapse of lamellipodia. To function in this module, fibronectin has to be present as puncta on the surface of LEM cells. To overcome contact inhibition in LEM cell...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (5): 784–794.
Published: 1 March 2017
...-structured functional tissues. Using the planarian Schmidtea mediterranea as a model, we identify β1-integrin as a crucial regulator of blastema architecture. β1-integrin(RNAi) animals formed small head blastemas with severe tissue disorganization, including ectopic neural spheroids containing differentiated...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (10): 1674–1687.
Published: 15 May 2016
... in adult mice slows proliferation of basal layer cells, leads to hair loss and impairs regeneration after wounding. Contact with the basal extracellular matrix and consequent integrin-Src signalling is a key determinant of the nuclear localisation of YAP/TAZ in basal layer cells and in skin tumours...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (5): 831–840.
Published: 1 March 2016
... transversum. Utilizing a small-molecule screen, we found that Lhx9 acts upstream of integrin-paxillin signaling and consistently demonstrate that either loss of Lhx9 or disruption of the integrin-paxillin pathway results in mis-positioning of the proepicardial organ and aberrant deposition of extracellular...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (2): 356–366.
Published: 15 January 2016
... that Crim1 acts in LE cells, where it colocalizes with and regulates the levels of active β1 integrin and of phosphorylated FAK and ERK. The RGD and transmembrane motifs of Crim1 are required for regulating FAK phosphorylation. These results identify an important function for Crim1 in the regulation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (4): 797–808.
Published: 15 February 2015
...Christopher J. Turner; Kwabena Badu-Nkansah; Denise Crowley; Arjan van der Flier; Richard O. Hynes The RGD-binding α5 and αv integrins have been shown to be key regulators of vascular smooth muscle cell (vSMC) function in vitro . However, their role on vSMCs during vascular development in vivo...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (15): 3072–3083.
Published: 1 August 2014
...Xiaojun Xie; Mary Gilbert; Lindsay Petley-Ragan; Vanessa J. Auld Many aspects of glial development are regulated by extracellular signals, including those from the extracellular matrix (ECM). Signals from the ECM are received by cell surface receptors, including the integrin family. Previously, we...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (6): 1342–1353.
Published: 15 March 2014
... processes, but how netrin signaling is coordinated with other pathways during invasion is poorly understood. Using the model of anchor cell (AC) invasion in C. elegans , we have previously shown that the integrin receptor heterodimer INA-1/PAT-3 promotes netrin receptor UNC-40 (DCC) localization...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (10): 2082–2092.
Published: 15 May 2013
... demonstrate that ephrin B1 is required in apical progenitors (APs) to maintain their apical adhesion. Mechanistically, we show that ephrin B1 controls cell-ECM adhesion by promoting apical localization of integrin β1 and we identify ADP-ribosylation factor 6 (Arf6) as an important effector of ephrin B1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (3): 627–638.
Published: 1 February 2013
... show that CAP regulates junctional membrane and cytoskeletal organization at the membrane-cytoskeletal interface of stretch-sensitive structures, and they implicate integrin signaling through a CAP/Vinculin protein complex in stretch-sensitive organ assembly and function. Funding This work...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (2): 255–265.
Published: 15 January 2013
..., and it is clear that stem cell-niche adhesion is crucial for stem cell self-renewal and is dynamically regulated. Here, we highlight recent progress in understanding adhesion between stem cells and their niche and how this adhesion is regulated. In addition to cadherins and integrins, many other families...
Journal Articles
Journal: Development
Development (2011) 138 (20): 4535–4544.
Published: 15 October 2011
... 12.5 kidneys revealed an almost complete absence of basement membrane proteins and reduced levels of α6 integrin and FGF2. mRNA levels for fibroblast growth factor 2 (FGF2) and mediators of the GDNF/RET and WNT11 signaling pathway were also decreased. Furthermore, collecting duct cells derived from...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (21): 3591–3601.
Published: 1 November 2010
...Charalampos Rallis; Sheena M. Pinchin; David Ish-Horowicz Integrins act at signalling crossroads, and their interactions with other signal transduction pathways are key to the regulation of normal and pathological cell cytoarchitecture and behaviour. Here, we describe a signalling cascade that acts...
Includes: Supplementary data