...Rikke Hoegsberg Agerskov; Pia Nyeng ABSTRACT The autonomic nervous system innervates the pancreas by sympathetic, parasympathetic and sensory branches during early organogenesis, starting with neural crest cell invasion and formation of an intrinsic neuronal network. Several studies have...

...David Castillo-Azofeifa; Justin T. Losacco; Ernesto Salcedo; Erin J. Golden; Thomas E. Finger; Linda A. Barlow The integrity of taste buds is intimately dependent on an intact gustatory innervation, yet the molecular nature of this dependency is unknown. Here, we show that differentiation of new...

... of organs, but the mechanisms leading to this arrangement are incompletely understood. Here, we show that vascular endothelial growth factor (VEGF) signaling profoundly affects both vascularization and innervation of the pancreatic islet. In mature islets, nerves are closely associated with capillaries...

...José Luis Muñoz-Bravo; María Hidalgo-Figueroa; Alberto Pascual; José López-Barneo; Alfonso Leal-Cerro; David A. Cano The mammalian pancreas is densely innervated by both the sympathetic and parasympathetic nervous systems, which control exocrine and endocrine secretion. During embryonic development...

.... To investigate Sulf regulation of developmental signaling, we have disrupted Sulf genes in mouse and identified redundant functions of Sulfs in GDNF-dependent neural innervation and enteric glial formation in the esophagus, resulting in esophageal contractile malfunction in Sulf1 -/- ;Sulf2 -/- mice. SULF1...

...Udayan Guha; William A. Gomes; Jayshree Samanta; Meenakshi Gupta; Frank L. Rice; John A. Kessler The role of target-derived BMP signaling in development of sensory ganglia and the sensory innervation of the skin was examined in transgenic animals that overexpress either the BMP inhibitor noggin...

... fiber nuclei. As development proceeded, slow myosin heavy chain transcripts spread throughout the length of myotomal fibers in order of their appearance. Explants of segments from embryos containing neural tube, notochord and somites 7-10, when incubated overnight, become innervated by motor neurons...

... the roles of Brn3a in neuronal differentiation and target innervation in the facial-stato-acoustic ganglion. We show that absence of Brn3a results in a substantial reduction in neuronal size, abnormal neuronal migration and downregulation of gene expression, including that of the neurotrophin receptor TrkC...

... concomitantly with or slightly following the advent of innervation. However, experimental evidence delineating the role of innervation in taste bud development is sparse and equivocal. Using two complementary experimental approaches, we demonstrate that taste cells differentiate fully in the complete absence...

... to be required postnatally. In Nt-3 − / − mice, sympathetic fibers failed to invade pineal gland and external ear postnatally; whereas other targets of the external and internal carotid nerves, including the submandibular gland and the iris, displayed a normal complement of sympathetic innervation. Sympathetic...

... of innervation in adult myogenesis is unclear. In males there is an additional muscle, which is unique to abdominal segment 5 (A5). This male specific muscle forms from the same pool of myoblasts as other dorsal muscles in A5 but develops several distinctive characteristics. Previous work indicates the genotype...

...Brian A. Mozer; Seymour Benzer ABSTRACT The development of the lamina, the first optic ganglion of the fly visual system, depends on inductive cues from the innervating photoreceptor axons. lacZ expression from a Pelement insertion, A72, occurs in the anlage of the lamina coincident with axon...

...Kendal Broadie; Michael Bate ABSTRACT We have examined the role of innervation in directing embryonic myogenesis, using a mutant ( prospero ), which delays the pioneering of peripheral motor nerves of the Drosophila embryo. In the absence of motor nerves, myoblasts fuse normally to form syncytial...

... regulators is under the control of innervation and humoral factors and may mediate differential control of contractile protein gene expression in adult muscle. * Authors for correspondence 17 05 1993 © 1993 by Company of Biologists 1993 MyoD Myogenin skeletal muscle innervation...

...Joyce Fernandes; K. VijayRaghavan ABSTRACT We have examined the development of innervation to the indirect flight muscles of Drosophila . During metamorphosis, the larval intersegmental nerve of the mesothorax is remodelled to innervate the dorsal longitudinal muscles and two of the dorsoventral...

... of motoneuron survival in vivo by activity blockade may not be mediated by an up-regulation of trophic factor synthesis in target cells; (2) postnatal innervation may regulate the production of putative muscle-derived neurotrophic factors; and (3) the synthesis or availability of trophic agents may be regulated...

...Sarah Harper; Alun M. Davies ABSTRACT To determine if the initial level of NGF mRNA in developing cutaneous epithelium is correlated with its final innervation density, we measured the concentration of NGF mRNA in the epithelia of the maxillary, mandibular and ophthalmic territories of trigeminal...

... the anteroposterior axis. The position of motoneurones innervating the duplicated posterior forearm extensor EMU was mapped by retrograde transport of horse radish peroxidase (HRP). The motor pool labelled from injection into the anteriorly duplicated EMU muscle is consistently similar to that supplying the posterior...

...David J. Goldhamer; Roy A. Tassava ABSTRACT Pulse and continuous labelling with [ 3 H]thymidine combined with mitotic index determinations provided data on the kinetics of cell cycling in innervated and denervated early and mid-bud forelimb blastemas of the adult newt, Notophthalmus viridescens...

...E. Canale; J. J. Smolich; G. R. Campbell ABSTRACT The development of the atrioventricular bundle (AVB) and ventricular Purkinje system and their innervation have been studied in fetal sheep from 27 to 140 days gestation (term is 147 days). The AVB initially consisted of a primordium, which lacked...