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Keywords: Inner ear
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Journal Articles
Journal: Development
Development (2021) 148 (14): dev199549.
Published: 21 July 2021
...Amandine Jarysta; Basile Tarchini ABSTRACT Sound transduction occurs in the hair bundle, the apical compartment of sensory hair cells in the inner ear. The hair bundle is formed of actin-based stereocilia aligned in rows of graded heights. It was previously shown that the GNAI-GPSM2 complex is part...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (5): dev196899.
Published: 9 March 2021
... in the mouse inner ear and also in other organs. Summary: We have established a quick genetic method, CRISPR-stop, that reveals the functions of lethal genes without the need to generate conditional knockout mice and breeding. CRISPR/Cas9 Base editing Rbm24 Atoh1 Hair cells Inner ear...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (22): dev192849.
Published: 19 November 2020
...Evan M. Ratzan; Anne M. Moon; Michael R. Deans ABSTRACT FGF8 signaling plays diverse roles in inner ear development, acting at multiple stages from otic placode induction to cellular differentiation in the organ of Corti. As a secreted morphogen with diverse functions, Fgf8 expression is likely...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (17): dev186015.
Published: 11 September 2020
... cascades in the inner ear remain largely unknown. Here, we have used Gfi1 cre ;RiboTag mice to evaluate changes to the hair cell translatome in the absence of GFI1. We identify a systematic downregulation of hair cell differentiation genes, concomitant with robust upregulation of neuronal genes in the GFI1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (15): dev183384.
Published: 14 August 2020
..., as a candidate for mediating the repressive function of let-7 in HC differentiation and inner ear morphogenesis. Our analysis uncovered an evolutionarily conserved let-7-5p -binding site within the chicken Chd7 gene and its human and murine homologs, and we show that let-7g overexpression in mice limits CHD7...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (13): dev191015.
Published: 8 July 2020
...Lisa D. Urness; Xiaofen Wang; Chaoying Li; Rolen M. Quadros; Donald W. Harms; Channabasavaiah B. Gurumurthy; Suzanne L. Mansour ABSTRACT Pan-otic CRE drivers enable gene regulation throughout the otic placode lineage, comprising the inner ear epithelium and neurons. However, intersection of extra...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (7): dev176750.
Published: 10 April 2020
...Simone Schwarzer; Nandini Asokan; Oliver Bludau; Jeongeun Chae; Veronika Kuscha; Jan Kaslin; Stefan Hans ABSTRACT The vertebrate inner ear employs sensory hair cells and neurons to mediate hearing and balance. In mammals, damaged hair cells and neurons are not regenerated. In contrast, hair cells...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (17): dev177188.
Published: 2 September 2019
... . Recent advances in the field of stem cell biology and organoid culture systems allow the expansion and differentiation of tissue-specific progenitors and pluripotent stem cells in vitro into functional hair cells and otic-like neurons. We discuss how inner ear organoids have been developed and how...
Journal Articles
Journal: Development
Development (2019) 146 (13): dev170522.
Published: 21 June 2019
...Aleta R. Steevens; Jenna C. Glatzer; Courtney C. Kellogg; Walter C. Low; Peter A. Santi; Amy E. Kiernan ABSTRACT The transcription factor sex determining region Y-box 2 (SOX2) is required for the formation of hair cells and supporting cells in the inner ear and is a widely used sensory marker...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (4): dev174748.
Published: 15 February 2019
...Chan Ho Hwang; James Keller; Charles Renner; Sho Ohta; Doris K. Wu ABSTRACT The semicircular canals of the mammalian inner ear are derived from epithelial pouches in which epithelial cells in the central region of each pouch undergo resorption, leaving behind the region at the rim to form a tube...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (20): dev168906.
Published: 17 October 2018
... for the generation of inner ear hair cells . Science   284 , 1837 - 1841 . 10.1126/science.284.5421.1837 Billon , P. , Bryant , E. E. , Joseph , S. A. , Nambiar , T. S. , Hayward , S. B. , Rothstein , R. and Ciccia , A. ( 2017 ). CRISPR-mediated base editing enables efficient...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (21): 3978–3989.
Published: 1 November 2017
... in an extracellular matrix. Cochlea Collagen Hearing Inner ear Planar cell polarity Tectorial membrane The tectorial membrane (TM) is an extracellular structure that spirals along the length of the cochlea, and lies over the organ of Corti ( Fig. 1 A). It attaches medially to the spiral limbus...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (20): 3766–3776.
Published: 15 October 2017
... to a polycarbonate filter (Sterlitech) and explants were cultured on floating filters at the air-liquid interface (see live imaging below). To visualize OC cells during cochlear development, inner ears from CD1 mice were collected at E14, E16 or P0 and fixed for 2 h in 4% PFA. Overlapping expression of CDKN1B...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (18): 3349–3360.
Published: 15 September 2017
...Allison M. Nishitani; Sho Ohta; Andrea R. Yung; Tony del Rio; Michael I. Gordon; Victoria E. Abraira; Evelyn C. Avilés; Gary C. Schoenwolf; Donna M. Fekete; Lisa V. Goodrich The vestibular system of the inner ear detects head position using three orthogonally oriented semicircular canals; even...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (12): 2228–2237.
Published: 15 June 2016
...Sho Ohta; Baolin Wang; Suzanne L. Mansour; Gary C. Schoenwolf The inner ear consists of two otocyst-derived, structurally and functionally distinct components: the dorsal vestibular and ventral auditory compartments. BMP signaling is required to form the vestibular compartment, but how...
Journal Articles
Journal: Development
Development (2015) 142 (16): 2792–2800.
Published: 15 August 2015
...-myc is required for proper morphogenesis of the cochlea and to control correct patterning of the organ of Corti. We show here that the Otx2 gene, a mammalian ortholog of the Drosophila orthodenticle homeobox gene, is a crucial target of N-myc during inner ear development. Otx2 expression is lost in N...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (4): 763–773.
Published: 15 February 2015
...Wei-Rui Ma; Jian Zhang The sensory patches of the vertebrate inner ear, which contain hair cells and supporting cells, are essential for hearing and balance functions. How the stereotypically organized sensory patches are formed remains to be determined. In this study, we isolated a zebrafish...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (21): 4362–4374.
Published: 1 November 2013
...Fan-Suo Geng; Leila Abbas; Sarah Baxendale; Celia J. Holdsworth; A. George Swanson; Krasimir Slanchev; Matthias Hammerschmidt; Jacek Topczewski; Tanya T. Whitfield Morphogenesis of the semicircular canal ducts in the vertebrate inner ear is a dramatic example of epithelial remodelling in the embryo...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (9): 1936–1945.
Published: 1 May 2013
...Stefan Hans; Anne Irmscher; Michael Brand Vertebrate inner ear development is a complex process that involves the induction of a common territory for otic and epibranchial precursors and their subsequent segregation into otic and epibranchial cell fates. In zebrafish, the otic-epibranchial...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (8): 1730–1739.
Published: 15 April 2013
... of Biologists Ltd 2013 Semicircular canals Vestibular system Inner ear Wnt β-catenin Morphogenesis Mouse The significance of the vestibular apparatus to human physiology and medicine was recognized with the awarding of the Nobel Prize to Róbert Bárány in 1914. Among his many...
Includes: Supplementary data