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Keywords: Inner ear
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Journal Articles
Journal: Development
Development (2023) 150 (24): dev201888.
Published: 11 December 2023
.... Atoh1 Tbx2 Supporting cell Inner hair cell Inner ear Regeneration National Natural Science Foundation of China http://dx.doi.org/10.13039/501100001809 32371054 32300811 82101217 82000985 National Key Research and Development Program of China 2021YFA1101804...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2023) 150 (21): dev201824.
Published: 8 November 2023
...Aitor Bañón; Berta Alsina ABSTRACT Cranial ganglia are aggregates of sensory neurons that mediate distinct types of sensation. The statoacoustic ganglion (SAG) develops into several lobes that are spatially arranged to connect appropriately with hair cells of the inner ear. To investigate...
Includes: Supplementary data
Journal Articles
In collection:
Human development
Journal: Development
Development (2023) 150 (19): dev201871.
Published: 5 October 2023
...Matthew R. Steinhart; Wouter H. van der Valk; Daniel Osorio; Sara A. Serdy; Jingyuan Zhang; Carl Nist-Lund; Jin Kim; Cynthia Moncada-Reid; Liang Sun; Jiyoon Lee; Karl R. Koehler ABSTRACT Inner ear development requires the coordination of cell types from distinct epithelial, mesenchymal and neuronal...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2023) 150 (9): dev200903.
Published: 3 May 2023
... in the ears, kidneys and branchial arches. Here, we have used Six1 -deficient mice, an animal model of the BOR syndrome, to investigate whether dysfunction of senescence underpins the developmental defects associated with SIX1 deficiency. We have focused on the developing inner ear, an organ...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (14): dev199549.
Published: 21 July 2021
...Amandine Jarysta; Basile Tarchini ABSTRACT Sound transduction occurs in the hair bundle, the apical compartment of sensory hair cells in the inner ear. The hair bundle is formed of actin-based stereocilia aligned in rows of graded heights. It was previously shown that the GNAI-GPSM2 complex is part...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (5): dev196899.
Published: 9 March 2021
... in the mouse inner ear and also in other organs. * These authors contributed equally to this work ‡ Author for correspondence ( zhiyongliu@ion.ac.cn ) Handling Editor: François Guillemot Competing interests The authors declare no competing or financial interests. 10 9 2020...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (22): dev192849.
Published: 19 November 2020
...Evan M. Ratzan; Anne M. Moon; Michael R. Deans ABSTRACT FGF8 signaling plays diverse roles in inner ear development, acting at multiple stages from otic placode induction to cellular differentiation in the organ of Corti. As a secreted morphogen with diverse functions, Fgf8 expression is likely...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (17): dev186015.
Published: 11 September 2020
... cascades in the inner ear remain largely unknown. Here, we have used Gfi1 cre ;RiboTag mice to evaluate changes to the hair cell translatome in the absence of GFI1. We identify a systematic downregulation of hair cell differentiation genes, concomitant with robust upregulation of neuronal genes in the GFI1...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2020) 147 (13): dev191015.
Published: 8 July 2020
...Lisa D. Urness; Xiaofen Wang; Chaoying Li; Rolen M. Quadros; Donald W. Harms; Channabasavaiah B. Gurumurthy; Suzanne L. Mansour ABSTRACT Pan-otic CRE drivers enable gene regulation throughout the otic placode lineage, comprising the inner ear epithelium and neurons. However, intersection of extra...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2019) 146 (4): dev174748.
Published: 15 February 2019
...Chan Ho Hwang; James Keller; Charles Renner; Sho Ohta; Doris K. Wu ABSTRACT The semicircular canals of the mammalian inner ear are derived from epithelial pouches in which epithelial cells in the central region of each pouch undergo resorption, leaving behind the region at the rim to form a tube...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (20): dev168906.
Published: 17 October 2018
.... To further confirm that base editing had occurred in the Atoh1 gene, DNA Sanger sequencing of inner ear tissues was performed. The results showed that base C (arrow in Fig. 2 I) had been converted to T (arrow in Fig. 2 J), leading to the coding CAG being changed to TAG, a stop codon. We also performed...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2017) 144 (20): 3766–3776.
Published: 15 October 2017
... at 12.5 days post-coitus to induce Cre ERT2 activity. Embryos were collected at E15, inner ears removed and fixed for 2 h in 4% paraformaldehyde (PFA). * Author for correspondence ( drivere@nidcd.nih.gov ) Competing interests The authors declare no competing or financial interests...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (18): 3349–3360.
Published: 15 September 2017
...Allison M. Nishitani; Sho Ohta; Andrea R. Yung; Tony del Rio; Michael I. Gordon; Victoria E. Abraira; Evelyn C. Avilés; Gary C. Schoenwolf; Donna M. Fekete; Lisa V. Goodrich The vestibular system of the inner ear detects head position using three orthogonally oriented semicircular canals; even...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (12): 2228–2237.
Published: 15 June 2016
...Sho Ohta; Baolin Wang; Suzanne L. Mansour; Gary C. Schoenwolf The inner ear consists of two otocyst-derived, structurally and functionally distinct components: the dorsal vestibular and ventral auditory compartments. BMP signaling is required to form the vestibular compartment, but how...