... largely unknown signaling mechanisms for regulating the scaling of cell numbers and cell plasticity during mouse development and following injury in the neonatal (P0-P14) cerebellum. This Review focuses on how the interplay between cell types is key to morphogenesis, production of robust neural circuits...

...Ian J. Begeman; Kwangdeok Shin; Daniel Osorio-Méndez; Andrew Kurth; Nutishia Lee; Trevor J. Chamberlain; Francisco J. Pelegri; Junsu Kang ABSTRACT Heart regeneration in regeneration-competent organisms can be accomplished through the remodeling of gene expression in response to cardiac injury...

...Luigi Maddaluno; Corinne Urwyler; Sabine Werner Tissue injury initiates a complex repair process, which in some organisms can lead to the complete regeneration of a tissue. In mammals, however, the repair of most organs is imperfect and results in scar formation. Both regeneration and repair...

... of PBS or CPP. Two weeks later, bladders were harvested, stained to detect β-gal, and whole mounts were made from urothelium. Following injury, small blue cells that include Shh + progenitor cells will differentiate to larger blue superficial cells (arrowheads). (B) Quantification of the number of β...

... an important source of newly forming bone. By contrast, differentiated osteoblasts do not appear to contribute to repair of bone injuries in mammals; rather, osteoblasts form anew from mesenchymal stem cells. This raises the question whether osteoblast dedifferentiation is specific to appendage regeneration...

... multipotentiality under injury, and convert into mature β-cells. * Author for correspondence ( [email protected] ) Competing interests statement The authors declare no competing financial interests. 3 12 2012 © 2013. Published by The Company of Biologists Ltd 2013...

... responded to neural injury in a similar manner: both stab injury and degeneration of sensory axons in the brain caused by antennal ablation induced glial division. Eiger, a tumour necrosis factor superfamily ligand, appears to be a link between developmental PCD/neural injury and glial division, as glial...