...Maria Sanz-Navarro; Kerstin Seidel; Zhao Sun; Ludivine Bertonnier-Brouty; Brad A. Amendt; Ophir D. Klein; Frederic Michon ABSTRACT In mice, the incisors grow throughout the animal's life, and this continuous renewal is driven by dental epithelial and mesenchymal stem cells. Sox2 is a principal...

... present in the mammalian tooth and supporting tissues, and discusses their potential application for dental therapies. Dental Incisor MSCs Pulp Teeth Teeth are composed of two layers of mineral – an outer layer of enamel and an inner layer of dentine that encloses the soft inner...

... fossils, because the highly calcified enamel that covers teeth causes them to be among the best-preserved organs. As mammals entered new ecological niches, many changes in tooth number occurred, presumably as adaptations to new diets. For example, in contrast to humans, who have two incisors in each...

... and hematopoietic system, homeostasis is dependent on the continuous generation of differentiated progeny from stem cells. The rodent incisor, unlike human teeth, grows throughout the life of the animal and provides a prime example of an organ that rapidly deteriorates if newly differentiated cells cease to form...

...Thimios A. Mitsiadis; Irene Angeli; Chela James; Urban Lendahl; Paul T. Sharpe It is believed that mouse dentition is determined by a prepatterning of the oral epithelium into molar (proximal) and incisor (distal) regions. The LIM homeodomain protein Islet1 (ISL1) is involved in the regulation...