... generation of previously hard-to-produce posterior spinal cord progenitors and MNs exhibiting a thoracic axial and, in particular, preganglionic columnar identity. Neuromesodermal progenitors Human pluripotent stem cells In vitro differentiation Motor neurons Regional identity Spinal cord...

...Nikolaos Konstantinides; Claude Desplan ABSTRACT Neuronal replacement therapies rely on the in vitro differentiation of specific cell types from embryonic or induced pluripotent stem cells, or on the direct reprogramming of differentiated adult cells via the expression of transcription factors...

.../ Summary: Mutations in RFX6 cause the rare disorder Mitchell-Riley syndrome, which is characterised by pancreatic hypoplasia and neonatal diabetes, and is due to an early failure to form pancreatic endoderm. Genetic disease In vitro differentiation Mitchell-Riley syndrome Pancreas development...

... for correspondence (e-mail: [email protected] ) 20 4 2009 © 2009. 2009 ES cell In vitro differentiation Protein kinase Mesendoderm AW548124 (Pkdcc) Vlk Cleft palate Lung hypoplasia Delayed chondrocyte hypertrophy Gene mining has been facilitated by the recent completion...

... © 2001. 2001 PLC-γ1 Chimeric mice Renal dysplasia Hematopoiesis In vitro differentiation Phospholipase C (PLC) hydrolyzes phosphoinositides to generate the second messengers, inositol 1,4,5-trisphosphate (Ins P 3 ) and diacylglycerol (DAG). Then, Ins P 3 increases intracellular...

... a useful model for the study of developmental blood vessel formation. * Author for correspondence 31 10 1991 © 1992 by Company of Biologists 1992 vascular development endothelial cell murine ES cells in vitro differentiation Blood vessel formation is a complex process...