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Keywords: Ihh
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Journal Articles
Journal: Development
Development (2018) 145 (15): dev163519.
Published: 10 August 2018
... descend from scleraxis- and Sox9-expressing progenitors; however, Hyp entheses exhibit an expansion of Sox9-expressing cells, and enhanced BMP and IHH signaling. These results support a role for enhanced BMP and IHH signaling in the development of enthesopathy in XLH. * Author for correspondence...
Journal Articles
Journal: Development
Development (2016) 143 (10): 1811–1822.
Published: 15 May 2016
... reveals a feed-forward loop controlling FGFR3 signaling in growth plate chondrocytes. FGF signaling PTHLH IHH Skeletal development Endochondral bone formation Osteoblast Chondrocyte Mouse Human genetic disease and conditional gene inactivation experiments in mice have demonstrated...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (5): 817–831.
Published: 1 March 2015
.../j.devcel.2005.02.013 Hilton , M. J. , Tu , X. , Cook , J. , Hu , H. and Long , F. ( 2005 ). Ihh controls cartilage development by antagonizing Gli3, but requires additional effectors to regulate osteoblast and vascular development . Development   132 , 4339 - 4351 . 10.1242...
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Journal: Development
Development (2009) 136 (10): 1697–1706.
Published: 15 May 2009
... of chondroitin chains(CS) and normal sulfation of heparan sulfate chains. In situ hybridization and immunohistochemical analysis of bm limb growth plates showed diminished Indian hedgehog (Ihh) signaling and abnormal Ihh protein distribution in the extracellular matrix. Consistent with the decrease in hedgehog...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (11): 1947–1956.
Published: 1 June 2008
...Kinglun Kingston Mak; Henry M. Kronenberg; Pao-Tien Chuang; Susan Mackem; Yingzi Yang Chondrocyte hypertrophy is an essential process required for endochondral bone formation. Proper regulation of chondrocyte hypertrophy is also required in postnatal cartilage homeostasis. Indian hedgehog (Ihh...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (16): 2903–2912.
Published: 15 August 2007
... of the primary cilium. The growth plate of Evc -/- mice shows delayed bone collar formation and advanced maturation of chondrocytes. Indian hedgehog( Ihh ) is expressed normally in the growth plates of Evc -/- mice, but expression of the Ihh downstream genes Ptch1 and Gli1 was markedly decreased. Recent studies...
Includes: Supplementary data
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Journal Articles
Journal: Development
Development (2006) 133 (15): 3039–3049.
Published: 1 August 2006
...-potential chondro-synovioprogenitors to become synovial connective tissue, by actively suppressing their chondrogenic potential. Furthermore, we show that Wnt9a is a temporal and spatial regulator of Indian hedgehog ( Ihh ), a central player of skeletogenesis. Loss of Wnt9a activity results in transient...
Includes: Supplementary data
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Journal: Development
Development (2004) 131 (6): 1309–1318.
Published: 15 March 2004
...Fanxin Long; Ung-il Chung; Shinsuke Ohba; Jill McMahon; Henry M. Kronenberg; Andrew P. McMahon Indian hedgehog (Ihh) is indispensable for development of the osteoblast lineage in the endochondral skeleton. In order to determine whether Ihh is directly required for osteoblast differentiation, we...
Journal Articles
Journal: Development
Development (2003) 130 (19): 4729–4739.
Published: 1 October 2003
... a precursor population expressing Cbfa1/Runx2 : a reversal of the normal sequence. Such secondary chondrocytes rapidly acquired a phenotype that is a compound of prehypertrophic and hypertrophic chondrocytes, exited from the cell cycle and upregulated Ihh . Pulse and pulse/chase experiments with BrdU...
Journal Articles
Journal: Development
Development (2003) 130 (13): 2967–2980.
Published: 1 July 2003
... glycoproteins that are required for embryonic tissue patterning and organogenesis ( Ingham and McMahon,2001 ; McMahon et al.,2003 ). The three mammalian Hh genes, sonic hedgehog( Shh ), Indian hedgehog ( Ihh ) and desert hedgehog( Dhh ), share the same signaling pathway components. The Hh receptor patched...
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