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Keywords: Ihh
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Journal Articles
Journal: Development
Development (2018) 145 (15): dev163519.
Published: 10 August 2018
... descend from scleraxis- and Sox9-expressing progenitors; however, Hyp entheses exhibit an expansion of Sox9-expressing cells, and enhanced BMP and IHH signaling. These results support a role for enhanced BMP and IHH signaling in the development of enthesopathy in XLH. Previous studies have...
Journal Articles
Journal: Development
Development (2016) 143 (10): 1811–1822.
Published: 15 May 2016
... - 107 . 10.1530/JME-10-0177 Chen , L. , Li , C. , Qiao , W. , Xu , X. and Deng , C. ( 2001 ). A Ser(365)-->Cys mutation of fibroblast growth factor receptor 3 in mouse downregulates Ihh/PTHrP signals and causes severe achondroplasia . Hum. Mol. Genet.   10 , 457 - 465...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (5): 817–831.
Published: 01 March 2015
... express the transcription factors Sox5, Sox6 and Sox9, and the structural proteins collagen, type II, α1 (Col2a1) and aggrecan (Acan). The next stage of maturation into prehypertrophic chondrocytes is marked by the expression of both parathyroid hormone 1 receptor (Pth1r) and Indian hedgehog (Ihh...
Journal Articles
Journal: Development
Development (2009) 136 (24): 4143–4153.
Published: 15 December 2009
... −/− growth plate, the typical columnar structure of proliferative chondrocytes is disturbed. The proliferative zone is shortened, whereas the hypertrophic zone is transiently expanded. The expression of Indian hedgehog ( Ihh ) is markedly decreased, whereas the expression of other chondrocyte marker genes...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (24): 4177–4185.
Published: 15 December 2009
...Kyu Sang Joeng; Fanxin Long Indian hedgehog (Ihh) critically regulates multiple aspects of endochondral bone development. Although it is generally believed that all Ihh functions are mediated by the Gli family of transcription activators and repressors, formal genetic proof for this notion has...
Journal Articles
Journal: Development
Development (2009) 136 (10): 1697–1706.
Published: 15 May 2009
... of chondroitin chains(CS) and normal sulfation of heparan sulfate chains. In situ hybridization and immunohistochemical analysis of bm limb growth plates showed diminished Indian hedgehog (Ihh) signaling and abnormal Ihh protein distribution in the extracellular matrix. Consistent with the decrease in hedgehog...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (11): 1947–1956.
Published: 01 June 2008
...Kinglun Kingston Mak; Henry M. Kronenberg; Pao-Tien Chuang; Susan Mackem; Yingzi Yang Chondrocyte hypertrophy is an essential process required for endochondral bone formation. Proper regulation of chondrocyte hypertrophy is also required in postnatal cartilage homeostasis. Indian hedgehog (Ihh...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (16): 2903–2912.
Published: 15 August 2007
... of the primary cilium. The growth plate of Evc -/- mice shows delayed bone collar formation and advanced maturation of chondrocytes. Indian hedgehog( Ihh ) is expressed normally in the growth plates of Evc -/- mice, but expression of the Ihh downstream genes Ptch1 and Gli1 was markedly decreased. Recent studies...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (18): 3695–3707.
Published: 15 September 2006
...Kingston Kinglun Mak; Miao-Hsueh Chen; Timothy F. Day; Pao-Tien Chuang; Yingzi Yang Both the Wnt/β-catenin and Ihh signaling pathways play essential roles in crucial aspects of endochondral ossification: osteoblast differentiation,chondrocyte proliferation and hypertrophy. To understand the genetic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (15): 3039–3049.
Published: 01 August 2006
...-potential chondro-synovioprogenitors to become synovial connective tissue, by actively suppressing their chondrogenic potential. Furthermore, we show that Wnt9a is a temporal and spatial regulator of Indian hedgehog ( Ihh ), a central player of skeletogenesis. Loss of Wnt9a activity results in transient...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (19): 4339–4351.
Published: 01 October 2005
...Matthew J. Hilton; Xiaolin Tu; Julie Cook; Hongliang Hu; Fanxin Long Indian hedgehog (Ihh) controls multiple aspects of endochondral skeletal development, including proliferation and maturation of chondrocytes,osteoblast development and cartilage vascularization. Although it is known that Gli...
Journal Articles
Journal: Development
Development (2004) 131 (20): 5009–5019.
Published: 15 October 2004
... cell fate remains largely uncharacterised. In order to determine whether the three vertebrate hedgehog molecules play a role in regulating epidermal renewal we overexpressed sonic( Shh ), desert ( Dhh ) and Indian ( Ihh ) hedgehog in the basal cells of mouse skin under the control of the human keratin...
Journal Articles
Journal: Development
Development (2004) 131 (6): 1309–1318.
Published: 15 March 2004
...Fanxin Long; Ung-il Chung; Shinsuke Ohba; Jill McMahon; Henry M. Kronenberg; Andrew P. McMahon Indian hedgehog (Ihh) is indispensable for development of the osteoblast lineage in the endochondral skeleton. In order to determine whether Ihh is directly required for osteoblast differentiation, we...
Journal Articles
Journal: Development
Development (2003) 130 (19): 4729–4739.
Published: 01 October 2003
... a precursor population expressing Cbfa1/Runx2 : a reversal of the normal sequence. Such secondary chondrocytes rapidly acquired a phenotype that is a compound of prehypertrophic and hypertrophic chondrocytes, exited from the cell cycle and upregulated Ihh . Pulse and pulse/chase experiments with BrdU...
Journal Articles
Journal: Development
Development (2003) 130 (13): 2967–2980.
Published: 01 July 2003
... plate, and subsequently from the ventral forebrain neuroepithelium( Marti et al., 1995 ), patterns ventral forebrain structures including the hypothalamus and optic vesicles( Chiang et al., 1996 ; Rubenstein and Beachy, 1998 ). At later developmental stages, Shh and Ihh are expressed...
Journal Articles
Journal: Development
Development (2001) 128 (24): 5099–5108.
Published: 15 December 2001
...Fanxin Long; Xiaoyan M. Zhang; Seth Karp; Yingzi Yang; Andrew P. McMahon Indian hedgehog (Ihh), one of the three mammalian hedgehog (Hh) proteins, coordinates proliferation and differentiation of chondrocytes during endochondral bone development. Smoothened (Smo) is a transmembrane protein...
Journal Articles
Journal: Development
Development (2001) 128 (22): 4523–4534.
Published: 15 November 2001
...Eleonora Minina; Hans Markus Wenzel; Conny Kreschel; Seth Karp; William Gaffield; Andrew P. McMahon; Andrea Vortkamp During endochondral ossification, two secreted signals, Indian hedgehog (Ihh) and parathyroid hormone-related protein (PTHrP), have been shown to form a negative feedback loop...