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Keywords: Igf2/H19 locus
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Journal Articles

De novo DNA methylation through the 5′-segment of the H19 ICR maintains its imprint during early embryogenesis

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Hitomi Matsuzaki, Eiichi Okamura, Takuya Takahashi, Aki Ushiki, Toshinobu Nakamura, Toru Nakano, Kenichiro Hata, Akiyoshi Fukamizu, Keiji Tanimoto
Journal: Development
Development (2015) 142 (22): 3833–3844.
https://doi.org/10.1242/dev.126003
Published: 15 November 2015
... article: In the mouse early embryo, H19 ICR imprinting is achieved through maternally inherited DNMT3A- and DNMT3L-mediated de novo methylation and requires a specific 5′ region of the locus. DNA methylation Genomic imprinting Igf2/H19 locus Early embryogenesis Genomic imprinting...
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Includes: Supplementary data