1-13 of 13
Keywords: Igf2
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles
Journal: Development
Development (2017) 144 (19): 3533–3546.
Published: 1 October 2017
... understood. Recently, an IGF2 mutation was identified in humans with early postnatal growth restriction. Here, we show that IGF2 is essential for longitudinal and appositional murine postnatal bone development, which involves proper timing of chondrocyte maturation and perichondrial cell differentiation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (2): 203–213.
Published: 15 January 2011
...Sylvie Nathalie Hardouin; Ruolin Guo; Paul-Henri Romeo; Andras Nagy; Jane E. Aubin During embryonic development, Igf2 gene transcription is highly regulated through the use of several promoters whose specific roles are not defined. Here, we show that loss-of-function of one of these promoters, Igf2...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2009) 136 (20): 3413–3421.
Published: 15 October 2009
... phenotype, due to a cis effect of the H19 locus on the adjacent Igf2 gene. To explore the function of the RNA itself, we produced transgenic mice overexpressing H19 . We observed postnatal growth reduction in two independent transgenic lines and detected a decrease of Igf2 expression in embryos...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2002) 129 (7): 1657–1668.
Published: 1 April 2002
... cluster of imprinted genes. We show that the mutation is an inversion, whose breakpoint distal to H19 disrupts and thus identifies an enhancer for Igf2 expression in skeletal muscle and tongue, and separates the gene from other mesodermal and extra-embryonic enhancers. Paternal transmission of Mnt leads...
Journal Articles
Journal: Development
Development (2002) 129 (5): 1205–1213.
Published: 1 March 2002
...Robert A. Drewell; Katharine L. Arney; Takahiro Arima; Sheila C. Barton; James D. Brenton; M. Azim Surani The reciprocally imprinted H19 and Igf2 genes form a co-ordinately regulated 130 kb unit in the mouse controlled by widely dispersed enhancers, epigenetically modified silencers...
Journal Articles
Journal: Development
Development (2000) 127 (18): 3923–3930.
Published: 15 September 2000
...Justin F-X. Ainscough; Rosalind M. John,; Sheila C. Barton; M. Azim Surani ABSTRACT Igf2 and H19 are closely linked and reciprocally expressed genes on distal chromosome 7 in the mouse. We have previously shown that a 130 kb YAC transgene contains multiple tissue-specific enhancers for expression...
Journal Articles
Journal Articles
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (1995) 121 (2): 309–316.
Published: 1 February 1995
...Tomas J. Ekström; Hengmi Cui; Xuri Li; Rolf Ohlsson ABSTRACT IGF2 has been shown to be expressed preferentially from the paternally derived allele, although the maternal allele can be found active during both prenatal and postnatal development as well as in neoplastic tumours in humans. We...
Journal Articles