.... In this study, we report that deletion of Isl1 in the mouse mandibular epithelium leads to aglossia due to myoblast migration defects. Isl1 regulates the expression pattern of chemokine ligand 12 ( Cxcl12 ) in the first branchial arch through the Shh/Wnt5a cascade. Cxcl12 + mesenchymal cells in Isl1 ShhCre...

... of mammalian retina cells. Isl1 Ldb1 Lhx2 Retinogenesis United States - Israel Binational Science Foundation 2013016 Israel Academy of Sciences and Humanities 10.13039/501100003973 228/14 Claire and Amédée Maratier Institute for the Study of Blindness and Visual...

... that the LIM-homeodomain transcription factor Isl1 is expressed in several subpopulations of developing arcuate neurons and plays crucial roles in their fate specification. Mice with conditional deletion of the Isl1 gene in developing hypothalamus display severe deficits in both feeding and linear growth...

... receptor CXCR4. Interestingly, the absence of CXCR4 signaling in spinal MNs is known to result in improper extension of the axons into the dorsal side of the spinal cord. Here, we report that the MN-specific ISL1-LHX3 complex directly transactivates the Stam1 gene and that STAM1 functions in determining...

... Highlighted article: In the mouse spinal cord, single-stranded DNA binding proteins are key cofactors in LIM-containing complexes, recruiting histone-modifying enzymes to promote transcription. NLI Ldb1 Isl1 Lhx3 Motor neuron V2a-interneuron Spinal cord The LIM homeodomain (LIM-HD) family...

... of particular sets of skeletal muscles or visceral organs. MN diversification depends on the coordinated action of several transcriptional regulators including the LIM-HD factor Isl1, which is crucial for MN survival and fate determination. However, how these regulators cooperate to establish each MN subtype...

... into mature SIN subtypes is regulated by the combinatorial activity of the LIM homeodomain proteins Lhx6, Lhx7 (Lhx8) and Isl1. These studies suggest that a LIM homeodomain transcriptional code confers cell-fate specification and neurotransmitter identity in neuronal subpopulations of the ventral forebrain...

... proteins Isl1 and Isl2 and LIM-only protein Lmo4 influences the assembly and function of complexes involved in the generation of spinal motor neurons (MNs) and V2a interneurons(INs). Reducing the levels of Islet proteins using a graded series of mutations favored V2a IN differentiation at the expense of MN...

... that the LIM homeodomain transcription factor islet 1 (Isl1) marks a subset of cardiac progenitors. Here, we perform lineage studies with an Isl1Cre mouse line to demonstrate that Isl1 also marks a subset of limb progenitors. In both cardiac and limb progenitors, Isl1 expression is downregulated as progenitors...

... the expression of each other as well as the regionally expressed developmental regulators Mash1 , the neurogenins and Dlx genes in telencephalic progenitors. Cerebral cortex Rbp1 Dlx Emx1 Isl1 Lateral ganglionic eminence Mash1 Neurogenins Striatum Mouse In the embryonic telencephalon...