... IPSC University of Cambridge http://dx.doi.org/10.13039/501100000735 We are currently witnessing the sixth mass extinction event for life on Earth, posing unprecedented challenges for conservation biology. In contrast to previous extinction events, human-driven species losses...

... that the original work is properly attributed. Summary: This Review describes how recent technological advances have shed light on the mechanisms underlying human lung development and disease, and outlines the future challenges in this field. Bronchi Alveolar ESC iPSC Progenitor Stem cell Lung...

... stem cells (iPSCs). We find that fNPCs become progressively stiffer en route to pluripotency, and that this stiffening is mirrored by iPSCs becoming more compliant during differentiation towards the neural lineage. Furthermore, we show that the mechanical phenotype of iPSCs is comparable...

... and the resulting pathology. Zika Cortex iPSC Microcephaly Organoids The rapidly advancing field of stem cell biology continually provides new insights into basic biology and human disorders, as well as innovative approaches to develop new patient treatment strategies. In the past 10 years, human...

... ( DeVeale et al., 2013 ). In the late phase of reprogramming, which proceeds independently of exogenous reprogramming factor expression, the expression of endogenous OCT3/4 reaches a level similar to that of ESCs and iPSCs. By contrast, the expression of endogenous SOX2, a late reprogramming marker in both...

... Summary: An approach to assess the chimera-forming ability of PSCs is developed and used to assess the developmental potential of rodent, monkey and human PSCs. Chimera Pluripotency ESC iPSC EpiSC Criteria exist for assessing pluripotency, a category of biological plasticity...