... and Leroitb , D. ( 1990 ). Cellular pattern of insulin-like growth factor-I (IGF-I) and type I IGF receptor gene expression in early organogenesis: comparison with IGF-II gene expression . Mol. Endocrinol . 4 , 1386 – 1398 . 10.1210/mend-4-9-1386 Brewer , M. T. , Stetler , G. L...

... outside the forming spiral organ, in day 13 to 21 fetuses. High levels of IGF-II mRNA in the brain, besides the choroid plexus and the leptomeninges, were detected in hypothalamus, in the floor of the 3rd ventricle at all stages studied, in the pineal primordium at 18 days and in the pars intermedia...

...Paul V. Senior; Simon Byrne; William J. Brammar; Felix Beck ABSTRACT The insulin-like growth factor II (IGF-II) receptor is identical to the mannose-6-phosphate receptor (M-6-P), but its role as a somatomedin transducer is uncertain. IGF-II/M-6-P receptor expression was studied by in situ...

... growth factors IGF-I and -II have major effects on cell growth and differentiation in tissue culture. Recently their importance for in vivo development has been studied; IGF-II is predominant prenatally, with a probable local role in the differentiation of some mesodermally derived tissues. Ocular...

... histochemistry) and for Northern blotting. IGF-II mRNA is strongly expressed in liver, skeletal muscle, perichondrium, leptomeninges and choroid plexus of the newborn. Demonstrable levels fall dramatically in the liver at 18-20 days postnatally but persist for longer periods in muscle and remain undiminished...

...Fotini Stylianopoulou; Argiris Efstratiadis; Joseph Herbert; John Pintar The rat insulin-like growth factor II (IGF-II) gene, encoding a fetal somatomedin, expresses a family of transcripts in embryonic/fetal tissues, and also in the adult choroid plexus and the leptomeninges. We have localized IGF...

... mammalian development. 30 11 1987 © 1988 by Company of Biologists 1988 growth factor mammal epidermal growth factor EGF insulin-like growth factor IGF-I IGF-II transforming growth factor-beta TGF heparin-binding growth factor HBGF platelet-derived growth factor PDGF...