...Caroline N. Dealy; Robert A. Kosher ABSTRACT IGF-I, insulin, FGF-2 and FGF-4 have been implicated in the reciprocal interactions between the apical ectodermal ridge (AER) and underlying mesoderm required for outgrowth and patterning of the developing limb. To study further the roles of these growth...

...C. Ayer-Le Lievre; P.A. Ståhlbom; V. R. Sara ABSTRACT Insulin-like growth factors (IGF-I and -II) are present in the brain during development, with high levels of both being also found in the periphery particularly in the embryo. IGFs in the brain are believed to stimulate the proliferation...

...Felix Beck; N. J. Samani; S. Byrne; K. Morgan; R. Gebhard; W. J. Brammar ABSTRACT We describe the postnatal ontogeny and localization of insulin-like growth factors I and II (IGF-I and -II) in the rat. We have used oligodeoxyribonucleotide probes for in situ hybridization (hybridization...

... mammalian development. 30 11 1987 © 1988 by Company of Biologists 1988 growth factor mammal epidermal growth factor EGF insulin-like growth factor IGF-I IGF-II transforming growth factor-beta TGF heparin-binding growth factor HBGF platelet-derived growth factor PDGF...