... expression may be part of the normal process of rod genesis. Nrarp is thus part of a network that includes bHLH, Hes and Id genes, which regulate the number of Müller glia and rods in the postnatal retina. Notch signaling activates expression of Hes family members, which can transcriptionally repress...

... lineage commitment. Treatment of cultured neural progenitor cells with BMP4 induced expression of all four members of the inhibitor of differentiation (ID) family of helix-loop-helix transcriptional inhibitors and blocked oligodendrocyte (OL) lineage commitment. Overexpression of Id4 or Id2 but not Id1...

[email protected] ) 06 04 2000 08 02 2000 © 2000 by Company of Biologists 2000 TWIST FGF Craniosynostosis Suture ID FGFR BMP Intramembranous bone formation Mouse Human Except for the supraoccipital bone, the majority of the calvarial bones form by intramembranous...

... in the human placenta. In many cell lineages, bHLH factors are sequestered by members of the Id family, HLH proteins that lack the basic DNA binding domain (Inhibitor of D NA binding proteins (Id-1 to Id-4)). During differentiation of some tissues, Id expression declines, allowing bHLH factors to dimerize...