...Néstor Saiz; Joanna B. Grabarek; Nitin Sabherwal; Nancy Papalopulu; Berenika Plusa During mouse pre-implantation development, extra-embryonic primitive endoderm (PrE) and pluripotent epiblast precursors are specified in the inner cell mass (ICM) of the early blastocyst in a ‘salt and pepper’ manner...

... endoderm (PrE). A subset of cells within the inner cell mass (ICM) of the blastocyst does not respond to differentiation signals and forms the pluripotent epiblast, which gives rise to all of the tissues in the adult body. How this group of cells is set aside remains unknown. Recent studies documented...

...Yojiro Yamanaka; Fredrik Lanner; Janet Rossant Primitive endoderm (PE) and epiblast (EPI) are two lineages derived from the inner cell mass (ICM) of the E3.5 blastocyst. Recent studies showed that EPI and PE progenitors expressing the lineage-specific transcriptional factors Nanog and Gata6...

... the restriction of ICM cell fate preceding cell sorting. Despite this, our live imaging data revealed an upregulation of Pdgfrα H2B-GFP expression in cells lining the blastocyst cavity and downregulation in deeper-lying cells, supporting a role for positional signals. The variety of behaviours of GFP-positive...

... by Company of Biologists 1995 mouse embryo blastocyst trophectoderm ICM epithelium cell adhesion desmosomes desmocollins cadherin reverse-transcriptase cDNA amplification The mouse early blastocyst (32-to 64-cell stage) is composed of two distinct tissues, an outer polarised...

...V. E. Papaioannou; K. M. Ebert Total cell number as well as differential cell numbers representing the inner cell mass (ICM) and trophectoderm were determined by a differential staining technique for preimplantation pig embryos recovered between 5 and 8 days after the onset of oestrus. Total cell...

... contribute preferentially to the inner cell mass as a result of being early-flattening cells. 02 03 1987 © 1987 by Company of Biologists 1987 mouse compaction division order lineage ICM cell division The mouse expanded blastocyst contains two distinct and committed cell...

... ( Fig. 2C,D ); (3) adjacent to, but not overlapping, the ICM, and (4) partly or wholly overlapping the ICM ( Fig. 2E,F ). The results are recorded in Table 3 , and show that the position of labelled cells in the nascent blastocyst does appear to influence the position of their progeny with respect...

..., as a population, are a little ahead of inside cells in their cell cycling. Additionally we present evidence that, within at least some individual inner cell masses (ICM), there is intraembryo variation in the time at which inside cell developmental potential becomes restricted. 21 11 1984 Copyright ©...