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Keywords: Hyperpolarization
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Journal Articles

Initiation of human myoblast differentiation via dephosphorylation of Kir2.1 K + channels at tyrosine 242

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Valérie Hinard, Dominique Belin, Stéphane Konig, Charles Roland Bader, Laurent Bernheim
Journal: Development
Development (2008) 135 (5): 859–867.
https://doi.org/10.1242/dev.011387
Published: 1 March 2008
... causes a negative shift (hyperpolarization) of the resting potential of myoblasts. After exploring various mechanisms, we found that this upregulation of Kir2.1 was due to dephosphorylation of the channel itself. Application of genistein,a tyrosine kinase inhibitor, increased Kir2.1 activity...
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Journal Articles

The calcineurin pathway links hyperpolarization (Kir2.1)-induced Ca 2+ signals to human myoblast differentiation and fusion

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Stéphane Konig, Anne Béguet, Charles R. Bader, Laurent Bernheim
Journal: Development
Development (2006) 133 (16): 3107–3114.
https://doi.org/10.1242/dev.02479
Published: 15 August 2006
...Stéphane Konig; Anne Béguet; Charles R. Bader; Laurent Bernheim In human myoblasts triggered to differentiate, a hyperpolarization,resulting from K + channel (Kir2.1) activation, allows the generation of an intracellular Ca 2+ signal. This signal induces an increase in expression/activity of two...
View articletitled, The calcineurin pathway links hyperpolarization (Kir2.1)-induced Ca 2+ signals to human myoblast differentiation and fusion
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