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Keywords: Hyperplasia
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Journal Articles
Journal: Development
Development (2023) 150 (21): dev202054.
Published: 24 October 2023
... relative hypertrophy or hyperplasia in the mutant hearts. This finding was confirmed with echocardiography, which demonstrated smaller left ventricular chamber size, as assessed by end diastolic diameter, but no significant difference in wall thickness, resulting in an increase in relative wall thickness...
Journal Articles
Journal: Development
Development (2013) 140 (17): 3657–3668.
Published: 1 September 2013
... and layer-specific block of cell cycle progression. The number of cells generated by this glial progenitor and hence the control of perineurial hyperplasia correlate with the length of the abdominal nerves. By contrast, the wrapping and subperineurial glia layers show enormous hypertrophy in response...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (9): 1675–1685.
Published: 1 May 2011
... the role of epidermal cilia. Here, epidermal cilia function was analyzed using conditional alleles of the ciliogenic genes Ift88 and Kif3a . At birth, epidermal cilia mutants appeared normal, but developed basaloid hyperplasia and ingrowths into the dermis of the ventrum with age. In addition, follicles...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (9): 1423–1432.
Published: 1 May 2009
... ) 19 2 2009 © 2009. 2009 Hedgehog SMO Ductal morphogenesis Hyperplasia Pituitary isograft Tissue interaction Mouse Mammary gland development requires both systemic hormones and local growth factor-mediated tissue interactions. Classical hormone ablation/replacement...
Journal Articles
Journal: Development
Development (2008) 135 (7): 1259–1269.
Published: 1 April 2008
...Michaël Hebeisen; Richard Roy Cdc25 phosphatases are key positive cell cycle regulators that coordinate cell divisions with growth and morphogenesis in many organisms. Intriguingly in C. elegans , two cdc-25.1(gf) mutations induce tissue-specific and temporally restricted hyperplasia...
Journal Articles
Journal Articles
Journal: Development
Development (2000) 127 (23): 5071–5082.
Published: 1 December 2000
... ; it appears that lin-23 and MET30 are orthologs, and that sel-10 and CDC4 are orthologs. Both Met30p and Cdc4p form SCF complexes containing the cullin Cdc53p (see Deshaies, 1999 ). The C. elegans homolog of CDC53, cul-1 , has a hyperplasia mutant phenotype similar to lin-23 ( Kipreos et al...
Journal Articles
Journal: Development
Development (2000) 127 (22): 4949–4958.
Published: 15 November 2000
... by expressing the Cre recombinase gene under control of the MMTV-LTR. By the age of five weeks, Bcl-x conditional mutant mice exhibited hyperproliferation of megakaryocytes and a decline in the number of circulating platelets. Three-month-old animals suffered from severe hemolytic anemia, hyperplasia...
Journal Articles
Journal: Development
Development (1998) 125 (1): 1–9.
Published: 1 January 1998
... in Raf, MEK, MAPK and Ksr genes strongly suppress of RAS1 V12 -induced hyperplasia. Second, Ras effector loop mutants (E37G and Y40C) that disrupt the RAS-RAF interaction completely suppress RAS1 V12 -induced proliferation. Even though the RAS1 effector loop and the Ras-binding domain...
Journal Articles
Journal: Development
Development (1995) 121 (1): 1–10.
Published: 1 January 1995
..., suggesting that RAS1 may also act through signaling pathway(s) distinct from the MAPK cascade. * Author for correspondence 23 10 1997 08 12 1997 © 1995 by Company of Biologists 1995 Ras1 Cell proliferation Cell death Hyperplasia Drosophila Imaginal disc Our...
Journal Articles