... cardiac tissue is enriched in cis-regulatory elements predicted to bind EBF1 ( Lee et al., 2018 ), in this study we sought to determine the role of this bHLH transcription factor in cardiac development and physiology. We observed multiple defects in EBF1 KO hearts, including marked myocardial hyperplasia...

... and layer-specific block of cell cycle progression. The number of cells generated by this glial progenitor and hence the control of perineurial hyperplasia correlate with the length of the abdominal nerves. By contrast, the wrapping and subperineurial glia layers show enormous hypertrophy in response...

... the role of epidermal cilia. Here, epidermal cilia function was analyzed using conditional alleles of the ciliogenic genes Ift88 and Kif3a . At birth, epidermal cilia mutants appeared normal, but developed basaloid hyperplasia and ingrowths into the dermis of the ventrum with age. In addition, follicles...

... Ptch1/+ hyperplastic phenotype described previously ( Lewis et al., 1999 ; Moraes et al.,2007 ) is dependent on genetic background, with B6D2F1 and DBA2 mice expressing the mutant phenotype, whereas C57BL/6J and FVB mice do not show hyperplasia. The hyperplastic phenotype was also observed recently...

...Michaël Hebeisen; Richard Roy Cdc25 phosphatases are key positive cell cycle regulators that coordinate cell divisions with growth and morphogenesis in many organisms. Intriguingly in C. elegans , two cdc-25.1(gf) mutations induce tissue-specific and temporally restricted hyperplasia...

... and cyclin D1 transcript levels, and a shift in p63 variant expression towards the ΔNp63 form. The expression of ECM-degrading proteinases and their inhibitors was altered in pregnancy and involution. Nulliparous transgenic females developed mammary hyperplasia that comprised undifferentiated basal (K5/14...

... in response to developmental signals. * Author for correspondence (e-mail: [email protected] ) 02 09 200 11 09 2000 © 2000 by Company of Biologists 2000 Ubiquitin proteolytic pathway SCF Hyperplasia G 1 to G 0 transition cul-1 Caenorhabditis elegans...

... by expressing the Cre recombinase gene under control of the MMTV-LTR. By the age of five weeks, Bcl-x conditional mutant mice exhibited hyperproliferation of megakaryocytes and a decline in the number of circulating platelets. Three-month-old animals suffered from severe hemolytic anemia, hyperplasia...

..., suggesting that RAS1 may also act through signaling pathway(s) distinct from the MAPK cascade. * Author for correspondence 23 10 1997 08 12 1997 © 1998 by Company of Biologists 1998 Ras1 Cell proliferation Cell death Hyperplasia Drosophila Imaginal disc Ras has...

... ). In turn, RAS activation leads to the sequential activation of RAF, MEK and MAPK, the highly conserved MAP Kinase cascade (reviewed in Daum et al., 1994 ). Ras1 Cell proliferation Cell death Hyperplasia Drosophila Imaginal disc © 1995 by Company of Biologists 1995 23 10 1997...

..., the transient delay in somite formation had disappeared and there was no lag in myosin heavy chain expression between the lines. The phase delay in brachial somite formation, myogenic factors and myosin heavy chain expression may be associated with the observed myofiber hyperplasia in P-line quail by allowing...