...Szilvia Galgoczi; Albert Ruzo; Christian Markopoulos; Anna Yoney; Tien Phan-Everson; Shu Li; Tomomi Haremaki; Jakob J. Metzger; Fred Etoc; Ali H. Brivanlou ABSTRACT Huntington's disease (HD) is a fatal neurodegenerative disorder caused by an expansion of the CAG repeats in the huntingtin gene ( HTT...

...Albert Ruzo; Gist F. Croft; Jakob J. Metzger; Szilvia Galgoczi; Lauren J. Gerber; Cecilia Pellegrini; Hanbin Wang, Jr; Maria Fenner; Stephanie Tse; Adam Marks; Corbyn Nchako; Ali H. Brivanlou ABSTRACT Huntington's disease (HD) is a fatal neurodegenerative disease caused by expansion of CAG repeats...

... (hESCs) and induced pluripotent stem cells (hiPSCs) is fundamental for realising their promise in disease modelling, pharmaceutical drug screening and cell therapy for Huntington's disease. GABAergic medium-sized spiny neurons (MSNs) are the principal projection neurons of the striatum and specifically...

...: Brain lesion in mice reveals a latent neurogenic potential in striatal astrocytes, which can proliferate and generate new neuroblasts. Neural stem cells Parenchymal progenitors Stem cell quiescence Lesion-induced neurogenesis Huntington's disease Mouse In adult neurogenic niches...

... (MSNs) are the only neostriatum projection neurons, and their degeneration underlies some of the clinical features of Huntington’s disease. Using knowledge of human developmental biology and exposure to key neurodevelopmental molecules, human pluripotent stem (hPS) cells were induced to differentiate...

... of affected traits. Copyright © 1990 by Company of Biologists 1990 sex-linked modifying loci dosage-sensitive modifiers Drosophila variegation Huntington’s disease Genome imprinting may be operationally defined as the process that results in the gamete-of-origin-dependent modification...