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Keywords: Human pluripotent stem cells
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Journal Articles
Journal: Development
Development (2021) 148 (6): dev193839.
Published: 29 March 2021
... stratified squamous cell layer, accompanied by the replacement of unspecified mesenchyme with layers of muscle cells. Studies in animal models have provided significant insights into the roles of various signaling pathways in esophageal development. More recent studies using human pluripotent stem cells...
Journal Articles
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Human development
Journal: Development
Development (2021) 148 (6): dev194415.
Published: 23 March 2021
... neurodegeneration. Thus, it is a crucial parameter in the design of strategies aiming to produce MNs from human pluripotent stem cells (hPSCs) for regenerative medicine/disease modelling applications. However, the in vitro generation of posterior MNs corresponding to the thoracic/lumbosacral spinal cord has been...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (22): dev193920.
Published: 16 November 2020
... models Human pluripotent stem cells Finally, 3D bioprinting is an emerging field that could be relevant for the development of in vitro NMJ systems. A recent study described the feasibility of using bio-printed 3D hydrogel skeletons to support culture, differentiation and alignment of human...
Journal Articles
Journal: Development
Development (2020) 147 (20): dev193037.
Published: 29 October 2020
... during human blood cell development are not well understood. We used human pluripotent stem cell reporter lines to track the development of endothelial and haematopoietic populations in an in vitro model of human yolk-sac development. We identified SOX17 − CD34 + CD43 − endothelial cells at day 2 of...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (24): dev174441.
Published: 13 December 2019
... transcription factors TCF21 and WT1. Here, we show that this cell heterogeneity is conserved in human epicardium, regulated by BNC1 and associated with cell fate and function. Single cell RNA sequencing of epicardium derived from human pluripotent stem cells (hPSC-epi) revealed that distinct epicardial...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (23): dev178855.
Published: 04 December 2019
... proliferation and stratification whereas persistent Yap activation increases cell proliferation and causes aberrant stratification of the developing esophagus. We further demonstrated that the role of YAP signaling is conserved in the developing human esophagus by utilizing 3D human pluripotent stem cell (hPSC...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (1): dev171686.
Published: 09 January 2019
.... Zack; Melissa C. Skala; David M. Gamm ABSTRACT Numerous protocols have been described for producing neural retina from human pluripotent stem cells (hPSCs), many of which are based on the culture of 3D organoids. Although nearly all such methods yield at least partial segments of retinal structure with...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (23): 4405–4418.
Published: 01 December 2016
... methods in human pluripotent stem cells (hPSCs), and show that generation of sOPTiKD/KO hPSCs is simple, rapid and allows tightly controlled individual or multiplexed gene knockdown or knockout in hPSCs and in a wide variety of differentiated cells. Finally, we illustrate the general applicability of this...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (20): 3674–3685.
Published: 15 October 2016
... PSCs. Histone demethylase JMJD3 KDM6B Human pluripotent stem cells Hepatocytes Skeletal muscle Pluripotent stem cells (PSCs), such as human embryonic stem cells (hESCs) ( Thomson et al., 1998 ) and human induced pluripotent stem cells (hiPSCs) ( Takahashi et al., 2007 ; Yu et al...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (9): 1475–1481.
Published: 01 May 2016
...Derek T. Peters; Christopher A. Henderson; Curtis R. Warren; Max Friesen; Fang Xia; Caroline E. Becker; Kiran Musunuru; Chad A. Cowan ABSTRACT Hepatocyte-like cells (HLCs) are derived from human pluripotent stem cells (hPSCs) in vitro , but differentiation protocols commonly give rise to a...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (18): 3231–3238.
Published: 15 September 2015
...Cathelijne W. van den Berg; Satoshi Okawa; Susana M. Chuva de Sousa Lopes; Liesbeth van Iperen; Robert Passier; Stefan R. Braam; Leon G. Tertoolen; Antonio del Sol; Richard P. Davis; Christine L. Mummery Differentiated derivatives of human pluripotent stem cells (hPSCs) are often considered...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (8): 1528–1541.
Published: 15 April 2015
... CFs from human pluripotent stem cells (HPSCs) through an intermediate lateral plate mesoderm (LM) stage. HPSCs were initially differentiated to LM in the presence of FGF2 and high levels of BMP4. The LM was robustly differentiated to an epicardial lineage by activation of WNT, BMP and retinoic acid...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (4): 705–717.
Published: 15 February 2013
...Zengrong Zhu; Danwei Huangfu Developmental biology has long benefited from studies of classic model organisms. Recently, human pluripotent stem cells (hPSCs), including human embryonic stem cells and human induced pluripotent stem cells, have emerged as a new model system that offers unique...
Journal Articles
Journal: Development
Development (2012) 139 (7): 1247–1257.
Published: 01 April 2012
... of the neural plate ( Lamb et al., 1993 ; Zimmerman et al., 1996 ). Human pluripotent stem cells Neural commitment MicroRNA © 2012. 23 1 2012 Competing interests statement The authors declare no competing financial interests. * Author for correspondence...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (19): 4143–4153.
Published: 01 October 2011
... reproducible differentiation to occur. The differentiation towards a hepatocyte-like fate appeared to recapitulate many of the developmental stages normally associated with the formation of hepatocytes in vivo. In the current study, we addressed the feasibility of using human pluripotent stem cells to probe...
Includes: Supplementary data