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Keywords: Human embryonic stem cells
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Journal Articles
Journal Articles
Journal: Development
Development (2021) 148 (22): dev199378.
Published: 12 November 2021
... conservation observed. Single-cell transcriptomics analysis of human embryos previously enabled us to identify transcription factors, including the zinc-finger protein KLF17, that are enriched in the human epiblast and naïve human embryonic stem cells (hESCs). Here, we show that KLF17 is expressed coincident...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (19): dev199513.
Published: 5 October 2021
... derived from human embryonic stem cells (hESCs). Specifically, we observed a reduction in the extension of the ectodermal compartment that is associated with enhanced activin signaling. Surprisingly, rather than a cell-autonomous effect, tracking the dynamics of TGFβ signaling demonstrated that HTT-CAG...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2019) 146 (20): dev179093.
Published: 17 October 2019
.... , Chhabra , S. , Guerra , M. C. , Liu , L. and Warmflash , A. ( 2019 ). Rapid changes in morphogen concentration control self-organized patterning in human embryonic stem cells . eLife   8 , e40526 . 10.7554/eLife.40526 Hoodless , P. A. , Haerry , T. , Abdollah , S...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (16): dev175604.
Published: 29 August 2019
... (anterior) or trunk (posterior) identity based on the magnitude of the WNT signal used to induce them. Neural crest WNT dose/magnitude Anterior-posterior axis HOX genes Human embryonic stem cells Neural crest cells (NCCs) are multipotent embryonic cells that are exclusive to vertebrates...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (2): dev156844.
Published: 29 January 2018
... in the Huntingtin gene ( HTT ). Neither its pathogenic mechanisms nor the normal functions of HTT are well understood. To model HD in humans, we engineered a genetic allelic series of isogenic human embryonic stem cell (hESC) lines with graded increases in CAG repeat length. Neural differentiation of these lines...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (1): dev159905.
Published: 8 January 2018
.... , Cook , S. M. , Palpant , N. J. , et al. ( 2014 ). Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts . Nature   510 , 273 - 277 . 10.1038/nature13233 Chugh , A. R. , Beache , G. M. , Loughran , J. H. , Mewton , N. , Elmore , J. B...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2017) 144 (6): 1025–1034.
Published: 15 March 2017
... and apoptosis, in developing and adult brain. In addition, the RB family is required for self-renewal and survival of human embryonic stem cells (hESCs). Since little is known about the role of RB in human brain development, we investigated its function in cerebral organoids differentiated from gene-edited...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2012) 139 (5): 829–841.
Published: 1 March 2012
...Kathy K. Niakan; Jinnuo Han; Roger A. Pedersen; Carlos Simon; Renee A. Reijo Pera Understanding human pre-implantation development has important implications for assisted reproductive technology (ART) and for human embryonic stem cell (hESC)-based therapies. Owing to limited resources, the cellular...
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2006) 133 (6): 1193–1201.
Published: 15 March 2006
...Henia Darr; Yoav Mayshar; Nissim Benvenisty Human embryonic stem cells (HESCs) are pluripotent cells derived from the ICM of blastocyst stage embryos. As the factors needed for their growth are largely undefined, they are propagated on feeder cells or with conditioned media from feeder cells...
Includes: Supplementary data