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Keywords: Human embryo
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Journal Articles
Journal: Development
Development (2022) 149 (24): dev200988.
Published: 21 December 2022
.... Highlighted Article: Tankyrase inhibition suppresses trophectoderm induction to stabilise human naïve pluripotent stem cells. This effect is mediated by stabilising angiomotin to restrict YAP activity. YAP Human embryo Pluripotency Self-renewal Stem cell Trophectoderm Medical Research...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (19): dev189449.
Published: 9 October 2020
... and position) and the Hippo pathway effector YAP remains unknown. We used a highly quantitative approach to analyse information on the geometry and YAP localisation of individual blastomeres of mouse and human embryos. We identified the proportion of exposed cell surface area as most closely correlating...
Includes: Supplementary data
Journal Articles
In collection:
Human development
Journal: Development
Development (2020) 147 (14): dev190629.
Published: 17 July 2020
... development have so far been technically and ethically challenging. However, recent technical developments provide the tools to describe, manipulate and mimic human embryos in a dish, thus opening a new avenue to exploring human development. Here, I discuss the evidence that supports a role for the crosstalk...
Journal Articles
Journal: Development
Development (2019) 146 (7): dev172916.
Published: 3 April 2019
... pluripotent stem cells acquire competence for multilineage differentiation following a developmental trajectory that is comparable with the primate embryonic epiblast, and is facilitated by inhibition of the Wnt pathway. Competence Differentiation Epiblast Human embryo Lineage specification...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (15): 2748–2763.
Published: 1 August 2017
... expression of each gene. (D) Heatmap showing expression of all transposon families that are differentially expressed (log 2 FC>1.5, P <0.05). (E) Comparative expression of pluripotency markers in human embryo cells ( Blakeley et al., 2015 ; Yan et al., 2013 ), HNES cells, cR cells, conventional...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2015) 142 (18): 3073–3076.
Published: 15 September 2015
... bioinformatics databases are essential resources for researchers, particularly those whose access to primary tissue is limited. Archive resources The Carnegie collection ( www.ehd.org/virtual-human-embryo/ ) Seven thousand human embryos are stored in the Carnegie collection at the National Museum...
Journal Articles
Journal: Development
Development (2012) 139 (5): 829–841.
Published: 1 March 2012
... statement The authors declare no competing financial interests. © 2012. Human embryo Oocyte to embryo transition Zygote Cleavage division Blastocyst Human embryonic stem cells Aneuploidy Studies of mammalian embryo development, especially in the mouse, have provided...
Journal Articles
Journal: Development
Development (2002) 129 (17): 4147–4157.
Published: 1 September 2002
... hematopoietic cells in the human embryo and fetus originate in vascular walls. *Author for correspondence (e-mail: peault@vjf.inserm.fr ) 16 5 2002 © 2002. 2002 Human embryo Endothelium Hematopoietic stem cell Yolk sac Aorta Liver Bone marrow The first tissues...
Journal Articles
Journal Articles
Journal: Development
Development (1988) 104 (4): 565–574.
Published: 1 December 1988
... human embryo Normal mesenchymal cells, normal epithelial cells and many transformed epithelial cells require serum attachment factors and extracellular matrix proteins for growth and differentiation in vitro ( Barnes & Sato, 1980 ). More recent evidence strongly supports a role...
Journal Articles
Journal Articles
Journal: Development
Development (1986) 98 (1): 71–83.
Published: 1 November 1986
... Copyright © 1986 by Company of Biologists 1986 insulin growth factors cornea human embryo DNA synthesis eye The human cornea consists of three cellular layers; an outer epithelium, an intermediate stroma and an inner endothelial monolayer ( Hogan, Alvarado & Weddell, 1971 ; Waring...
Journal Articles