... of development, human embryos form a blastocyst composed of an inner cell mass and trophectoderm (TE) cells, the latter of which are progenitors of placental trophoblast. Here, we investigated the expression of transcripts in the human TE from early to late blastocyst stages. We identified enrichment...

... is mediated by stabilising angiomotin to restrict YAP activity. YAP Human embryo Pluripotency Self-renewal Stem cell Trophectoderm Medical Research Council http://dx.doi.org/10.13039/501100007155 MR/P00072X/1 G1100526/1 Medical Research Council http://dx.doi.org/10.13039...

... and position) and the Hippo pathway effector YAP remains unknown. We used a highly quantitative approach to analyse information on the geometry and YAP localisation of individual blastomeres of mouse and human embryos. We identified the proportion of exposed cell surface area as most closely correlating...

... development have so far been technically and ethically challenging. However, recent technical developments provide the tools to describe, manipulate and mimic human embryos in a dish, thus opening a new avenue to exploring human development. Here, I discuss the evidence that supports a role for the crosstalk...

... pluripotent stem cells acquire competence for multilineage differentiation following a developmental trajectory that is comparable with the primate embryonic epiblast, and is facilitated by inhibition of the Wnt pathway. Competence Differentiation Epiblast Human embryo Lineage specification...

... and DNA methylation of imprinting control regions . Mol. Cell   44 , 361 - 372 . 10.1016/j.molcel.2011.08.032 Reik , W. and Kelsey , G. ( 2014 ). Epigenetics: cellular memory erased in human embryos . Nature   511 , 540 - 541 . 10.1038/nature13648 Roode , M. , Blair...

... the same embryo. As predicted by the transcriptomic data, immunolocalization of EOMES, T brachyury, GDF15 and active β-catenin revealed differential expression among blastomeres of 8- to 10-cell human embryos. The UCSFB lines formed derivatives of the three germ layers and CDX2-positive progeny, from which...

... bioinformatics databases are essential resources for researchers, particularly those whose access to primary tissue is limited. Archive resources The Carnegie collection ( www.ehd.org/virtual-human-embryo/ ) Seven thousand human embryos are stored in the Carnegie collection at the National Museum...

... statement The authors declare no competing financial interests. © 2012. Human embryo Oocyte to embryo transition Zygote Cleavage division Blastocyst Human embryonic stem cells Aneuploidy Studies of mammalian embryo development, especially in the mouse, have provided...

... hematopoietic cells in the human embryo and fetus originate in vascular walls. *Author for correspondence (e-mail: [email protected] ) 16 5 2002 © 2002. 2002 Human embryo Endothelium Hematopoietic stem cell Yolk sac Aorta Liver Bone marrow The first tissues...

... hybridization molar pregnancy human embryo gene expression The embryonic forms of many vertebrates are much more closely similar than the resulting adult forms: embryonic development is characterized by evolutionary conservatism. The structures that are first to form serve as the framework on which...

... human embryo Normal mesenchymal cells, normal epithelial cells and many transformed epithelial cells require serum attachment factors and extracellular matrix proteins for growth and differentiation in vitro ( Barnes & Sato, 1980 ). More recent evidence strongly supports a role...

... of the reaction observed on tissue sections and to measure the relative mRNA abundance in different organs. 15 01 1987 © 1987 by Company of Biologists 1987 apolipoprotein B human embryo in situ hybridization lipid transport gene expression Many rapidly multiplying mammalian...

... Copyright © 1986 by Company of Biologists 1986 insulin growth factors cornea human embryo DNA synthesis eye The human cornea consists of three cellular layers; an outer epithelium, an intermediate stroma and an inner endothelial monolayer ( Hogan, Alvarado & Weddell, 1971 ; Waring...

...B. Hopkins; C. R. Sharpe; F. E. Baralle; C. F. Graham ABSTRACT In the liver and the yolk sack of 6–12 week postfertilization human embryos, we have detected RNA transcripts from the following apolipoprotein genes: AI, AII, B, CII, CIII and E. The mRNA from the apolipoprotein CIII gene...