... of development, human embryos form a blastocyst composed of an inner cell mass and trophectoderm (TE) cells, the latter of which are progenitors of placental trophoblast. Here, we investigated the expression of transcripts in the human TE from early to late blastocyst stages. We identified enrichment...

... by stabilising angiomotin to restrict YAP activity. YAP Human embryo Pluripotency Self-renewal Stem cell Trophectoderm Medical Research Council http://dx.doi.org/10.13039/501100007155 MR/P00072X/1 G1100526/1 Medical Research Council http://dx.doi.org/10.13039/501100007155...

... and position) and the Hippo pathway effector YAP remains unknown. We used a highly quantitative approach to analyse information on the geometry and YAP localisation of individual blastomeres of mouse and human embryos. We identified the proportion of exposed cell surface area as most closely correlating...

... development have so far been technically and ethically challenging. However, recent technical developments provide the tools to describe, manipulate and mimic human embryos in a dish, thus opening a new avenue to exploring human development. Here, I discuss the evidence that supports a role for the crosstalk...

... observed in human embryos in utero . This is a period of major change that appears to be crucial for establishing differentiation competence ( Rossant and Tam, 2017 ; Sheng, 2015 ; Smith, 2017 ). Notably, mouse naïve ES cells do not differentiate directly into germ cell or somatic lineages, but first...

... to both rodent ESCs and naïve cells in the human embryo ( Davidson et al., 2015 ; Huang et al., 2014 ). However, two culture conditions have now been described for sustaining reset hPSC phenotypes that exhibit a wide range of both global and specific properties expected for naïve pluripotency ( Takashima...

... the same embryo. As predicted by the transcriptomic data, immunolocalization of EOMES, T brachyury, GDF15 and active β-catenin revealed differential expression among blastomeres of 8- to 10-cell human embryos. The UCSFB lines formed derivatives of the three germ layers and CDX2-positive progeny, from which...

... – that provides researchers with access to human tissue and related services. Bioinformatics portals Congenital anomalies Gene expression Human development Human embryo Tissue bank Introduction An important goal of developmental biology is to understand human embryonic/fetal development...

... is currently known about human pre-implantation embryo development and highlight how further studies of human pre-implantation embryos can be used to improve ART and to fully harness the potential of hESCs for therapeutic goals. Historically, it has been difficult to obtain reliable human embryo gene...

... hematopoietic cells in the human embryo and fetus originate in vascular walls. *Author for correspondence (e-mail: [email protected] ) 16 5 2002 © 2002. 2002 Human embryo Endothelium Hematopoietic stem cell Yolk sac Aorta Liver Bone marrow The first tissues...

.... Gynecol. 31 , 665 – 671 . 10.1016/0002-9378(78)90829-3 * Author for correspondence 02 01 1990 © 1990 by Company of Biologists 1990 Hox-3 trophoblast in situ hybridization molar pregnancy human embryo gene expression The embryonic forms of many...

... human embryo Normal mesenchymal cells, normal epithelial cells and many transformed epithelial cells require serum attachment factors and extracellular matrix proteins for growth and differentiation in vitro ( Barnes & Sato, 1980 ). More recent evidence strongly supports a role...

... 01 1987 © 1987 by Company of Biologists 1987 apolipoprotein B human embryo in situ hybridization lipid transport gene expression Many rapidly multiplying mammalian cells in culture require a source of lipids (e.g. Chen & Kandutsch, 1981 ); both in culture...

... recently been established that IGF-II interacts with the human type I receptor at a site distinct from the IGF-I binding site (J. d’Ercole, personal communication). Competitive binding studies have also suggested another receptor population in the early human embryo, in which insulin will compete for IGF...

...B. Hopkins; C. R. Sharpe; F. E. Baralle; C. F. Graham ABSTRACT In the liver and the yolk sack of 6–12 week postfertilization human embryos, we have detected RNA transcripts from the following apolipoprotein genes: AI, AII, B, CII, CIII and E. The mRNA from the apolipoprotein CIII gene...